“a strong trend”

We describe a strong trend to lower [GSH] in males than in females on DOL 5, but we note that sexes were unbalanced in our cohort, with twice as many males as females, reducing our ability to accurately evaluate sex differences.

The fact that only 210 publications were written by single authors, with the remainder resulting from collaborations, highlights a strong trend toward collaborative research, both nationally and internationally, as reflected by the 26.47% proportion of international co-authorship.

The liver of Nudt7 -/- females fed the CD also exhibited a significant downregulation in the gene encoding monoglyceride lipase, Mgll , and a strong trend toward increased triacylglycerol excretion in the feces ( Fig. 7 G ), which could contribute to the diminished concentration of nonesterified fatty acids in the liver of these mice.

There was a significant main effect of treatment upon filopodia density, with a significant increase following TTX application only, and a strong trend to an increase following total silencing ( Figure 3Cii ).

There was also a strong trend toward a decrease in the percentage of lung area occupied by metastasis in mice bearing RALA–KO tumors compared to the other two groups (Fig. 3 a, bottom right panel).

Also, we found a strong trend that the proportion of HIV-DNA sequences contributing to identical sequence clusters is positively correlated with the proportion of infected HLA-DR+ T-cells, but not within their HLA-DR− counterpart.

[ 25 , 28 ] analyzed the pain relief effect in various factors, showing a strong trend of increased pain control with higher radiation dose ≥14 Gy, although without reaching statistical significance.

In our cohort the total implantation time did not differ significantly between the cephalic and subclavian vein access group; however, there was a strong trend toward longer implantation times when cephalic access failed and SVP was used as a bail‐out—this was primarily triggered by longer time to first lead placement.

There was a strong trend toward non-Europeans having poorer access to at least one hour of physical therapy per day during inpatient rehabilitation (aOR=0·67, 0·44-1·00).

However, there is a strong trend in previous literature in the professional field of social educators that has long contemplated the great challenge of incorporating this in educational centers (Machalík, 2020 ; Díez-Gutiérrez and Muñiz-Cortijo, 2022 ).

We noticed a strong trend for siRNA enrichment in gene flanking regions near transcription start sites (TSS) and transcription termination sites (TTS) (Figure 4D ).

Thus, we classified the studies as being imaging (direct image analysis of X-rays or CT scans) or nonimaging (eg, studies that analyzed blood metabolites), and there was a strong trend for nonimaging studies to score higher than imaging studies, which included the “objective of the study” (imaging study mean score 1.79, SE 0.08; nonimaging study mean score 2.18, SE 0.13; P =.02), “safety and quality” (imaging study mean score 0.16, SE 0.05; nonimaging study mean score 0.36, SE 0.14; P =.015), “nonmaleficence” (imaging study mean score 0.04, SE 0.02; nonimaging study mean score 0.18, SE 0.07; P =.05), and “number of services” (imaging study mean score 0.25, SE 0.06; nonimaging study mean score 0.55, SE 0.11; P =.02) subcomponents ( Multimedia Appendix 4 C,D).

Interestingly, BMP-dependent Smad1/5 showed a strong trend to increased activity as evident by a marked elevation of Ser 463/465 Smad1/5 phosphorylation in PAVSMC from 3 out of 4 analyzed PAH subjects compared to controls, as seen in Figure 2 A,D.

We also noted that the anti-Mi2 antibody was independently protective against cancer in our adjusted model, while anti-MDA-5 demonstrated a strong trend towards protection that narrowly missed statistical significance.

Currently, there is a strong trend in the discourse and policy communities, which supports the argument that robots will provide a solution to social and economic challenges associated with aging ( 15 , 16 ).

Consistently, ANXA5 KO MSCs showed a strong trend toward increased formation of fibroblast colonies (colony-forming units fibroblast; supplemental Figure 9 A) but decreased osteogenic and unchanged adipocytic differentiation ( supplemental Figure 9 B-C).

High-grade glioma PD-L1 expression has been identified in 6 (30%) of 20 pediatric high-grade glioma samples, 42 and larger studies in adults showed expression in 68% of 62 glioblastoma samples, with a strong trend for worse outcome in these patients. 43 In addition, a subset of pediatric high-grade glioma tumors has evidence of MSI, which reflects the increased mutational status of the tumor and the potential greater number of neoantigens that could induce a host immune response.

In the second approach, MDA‐MB‐231 cells had a strong trend toward lower Ki67 staining at all doses.

The results presented a strong trend toward higher prevalence of RCT in weaker upper extremities, and pointed out that the motor function of the affected side may be the independent predisposing factor for the RCTs.

Although anterior release has been considered a necessary and helpful ingredient in the correction of large curves, there is currently a strong trend away from it and towards more reliance on posterior release (osteotomy and spinal shortening) techniques.

Results A strong trend between a measure of ‘minimum ADC’ and methylation status was seen.

Analysis of the subcellular location of sex-biased genes, which were mostly MG, showed a strong trend toward localization in or around the cell membrane.

The fluorescence enhancement effect decreased with distance and as the size of the gold nanoparticles approached 100 nm (micro-order), the effect was replaced by a strong trend of quenching effect of the QDs ( Figure 9 a–f).

The comparison of neuropoietic coefficients from SB623 with parental MSCs reveals a strong trend that suggests a higher neuropoietic activity of SB623 than of parental MSCs.

If current data suggest a strong trend in favor of a particular approach with consistent results across studies, it may be more appropriate to refine existing methodologies rather than initiate extensive new trials.