“a strong trend”

During the second half of the twentieth century, there was a strong trend towards early retirement.

When both NHOF-1 and NHOF-5 were combined and their zero time controls compared with their corresponding levels at day 20, 39 metabolites were significantly altered but the previously reported citrate only showed a strong trend, because of a large outlier in the NHOF-1 control group (Supplementary Table S1A ).

The estimated marginal means suggest a strong trend for tickled female rats to pair more flat USVs with hopping and darting than tickled males and control rats.

[ 31 ] found no recent temporal trend in the representation of women among eponyms; Pillon [ 41 ], in contrast, demonstrated a strong trend to increasing representation of women since the mid-twentieth century.

We found a strong trend of increased IFIT1 and CH25H expressions in non-survived patients with P values of approximately 0.07–0.08 ( Fig. 2 A and B).

However, no significant differences between the groups for the diastolic blood pressure measurements were observed, together with a strong trend for systolic blood pressure.

There was also a strong trend toward MAE rates being higher in the clopidogrel‐treated IM/PM group compared with the clopidogrel‐treated NM/RM/UM group (Figure 1D and Table 4 ).

However, in a two-year double-blinded RCT of high-dose oral vitamin D 3 supplementation (20,000 IU/week) in another cohort of 68 patients with RRMS with lower disease activity we found only a strong trend for a reduction among patients without DMTs and no overall effect of increasing serum 25(OH)D levels on serum levels of NfL ( 10 ).

Evaluation of the Candidate Indicators on the Basis of Ecosystem Structure and Network Analyses Various candidate indicators showed a strong trend with increasing fishing pressure ( Tables 3 and 4 ).

Moreover, it has been shown that patients with CLL exhibit increased amounts of circulating immunosuppressive neutrophils (CD16 high CD62L dim ), and that, depending on the disease stage in the intermediate or advanced state, there is a strong trend toward an increase in the frequency of this TANs subset ( 59 ).

On average ∼4% of cells were classified as ACBs in WT PFF-treated neurons and, while there was a strong trend towards a reduced proportion of ACBs in sister cultures from LKO mice, there was no significant difference in the number of ACBs ( Fig. 3D ).

We found decreased expression of CB (and a strong trend toward a decrease in the density of CB+ interneurons) in the MOB of GK rats.

Moreover, α-synuclein pathology was significantly reduced in mice with preseeding ACY-738 administration, with a strong trend toward reduction after postseeding dosing.

Inhibition of p38 caused a significant enhancement of collagen type II and Sox9 expression coupled with a strong trend for suppression of collagen type I ( Fig. 5 B).

The high myeloid gene signature patients demonstrated a strong trend in prolonged overall survival from their bone metastasis diagnosis compared with the low myeloid gene signature patients ( Figure 1F ).

Linear regression analysis revealed that there was a strong trend between levels of RAN and KPNA2 (Figure 4D , R 2 = 0.4798) and levels of RAN and KPNB1 (Figure 4E , R 2 = 0.7591).

Based on the standard mentioned above, GUA~A, AGC~A, AAG~C, AGA~C, A~GUA, U~AGC, U~AAG, C~AAG, G~AGA, and U~AUG have a strong trend to exist in the helix of PRRSV nsp1 α gene and UUA~A, AUA~G, GUG~U, UCA~C, ACA~C, UAC~U, UAC~C, CAU~G, CGC~U, G~UUA, U~GUG, U~UCA, C~AGU, C~ACA, G~UAC, U~CAU, and U~CGC have a strong tendency to exist in the β -strand of the nsp1 α gene. 4.

In the luminal A, luminal B, and HER2 subtypes, ELF5 was significantly downregulated (fold change 0.02–0.13 compared to normal), while in the basal subtype there was a strong trend for increased ELF5 expression (1.96-fold compared with normal, FDR 0.053 in Limma voom analysis, 1.99-fold compared with normal, FDR 0.0008 in edgeR analysis) (Fig. 4a and Additional file 1 : Figure S4b).

Analyzing shorter periods, a strong trend in the increasing ROS level was detected at the TP of 50 min.

When analyzing the proliferation rate of leukemic cells by KI67 staining, a strong trend towards a higher percentage of proliferating cells was detected in the spleen of 1MT-treated mice compared to controls ( Figure 2 D; Supplementary Figure S2C for gating strategy), which might explain the loss of treatment efficacy over time.

Six out of seven specimens exhibited a strong trend of decreasing signal (maximal) strength between April and September 2014 (Fig. 6 ) followed by a more stationary period without a clear trend in the maximum signal.

44 , 45 On tumor RNA, we investigated the tumor-enriched pathways by GSEA, identifying key pathways related to cell membrane potential and ion homeostasis, particularly involving calcium and sodium channel activity, while a fourth pathway linked to these was reported with a strong trend (GO:0099604, GO:0005272, GO:0005217, GO:0005248).

Nevertheless, there is a strong trend for the above rule within each subcluster, indicating once more that the third base of the P-site codon influences the first base of the A-site codon.

10 Dreyfus and associates 7 demonstrated shock and cardiogenic shock in 23% of their TVE cohort and a strong trend of right ventricular dysfunction increasing mortality risk in patients undergoing isolated tricuspid valve surgery.

20 Relating to this, there was a strong trend of victims of sexual harassment not reporting and trying to simply ignore perpetrators, which may (in addition to not being aware of reporting options available) be also due to there being discomfort associated with reporting someone, or a lack of trust that any action would be taken: ‘if I am grab