None the less, a phase 3 trial combining IL-2 with a single melanoma antigen epitope has demonstrated a significant improvement in overall response rate, progression free survival, and a strong trend in improvement of overall survival compared to treatment with IL-2 alone [ 63 ].
A recent meta-analysis of over 270 000 people showed a strong trend for dairy intake protecting against hip fracture; the relative risk (RR) of hip fracture per daily glass of milk was 0.91, 95% CI 0.81 to 1.01. 9 In many industrialised nations, milk is often the most cost-effective strategy for achieving recommended levels of calcium intake at a population level.
This kind of feature became a strong trend, thanks to the fact that they can be easily obtained, since it is not necessary to perform the feature engineering work, which in general is a laborious task and may require a refined knowledge regarding the problem classes, and also regarding the techniques that support handcrafted descriptors.
In particular, the field of brain signal analysis has witnessed a strong trend towards multidimensional analysis of large data sets, for example, single-trial time-frequency analysis of high spatiotemporal resolution recordings.
In contrast, patients treated with MTH and a favourable neurological outcome showed a strong trend to lower S-100 serum levels being significant after 24 hours (CPC 1 to 2 = 0.56 vs.
Many studies have reported that females showed greater impact in vertical ground reaction forces (I-vGRF) and have a strong trend toward one-leg dominance with greater bilateral asymmetry during landing tasks compared to males [ 2 , 3 , 4 ].
ST131 isolates exhibited a strong trend in the inability to utilise five tested substrates: 5-keto-D-gluconate (5KG), D-ARAbinose (DARA), esculin, cellobiose and dulcitol, in comparison to other ST isolates.
However, there was a strong trend among GP-BSIs for a reduced time to de-escalation, which is important in the era of increasingly resistant organisms.
There is a strong trend, however, to change the ‘business as usual’ approach to decisions about allocating resources with four contributory factors.
AP showed a higher RMSE of 7.1165% compared to RC, but it had a high R 2 of 0.9791, indicating a strong trend.
miR-132-injected hippocampi displayed a strong trend toward reduced IBA1+ intensity around plaques and a significant reduction in CD68+ intensity per plaque (Fig. 6 K).
In a multivariate analysis including sIL‐2R, age was an independent prognostic factor and there was a strong trend toward worse 5‐year OS in patients with higher sIL‐2R (Table 3 ).
In predicting DCI, each presented a strong trend between increased score and DCI rate ( P for trend <0.001) (Fig. 2A ).
A strong trend toward PEFT methods like LoRA is evident, as they enable effective adaptation with minimal new parameters, preserving pre-trained knowledge ( 37 ).
Here we extend that observation by showing that there is a substantial amount of chem156F present in both OA and RA samples, with a strong trend toward increased chem156F in RA as compared to OA synovial fluids.
We then examined the coprecipitated H2BubiK120 levels and observed a strong trend for an increase of trained animals compared with naïve.
A strong trend to positive TST was associated with HIV negativity.
We found that the lower kallistatin/total protein ratio in BALF had a strong trend toward higher neutrophil counts in BALF and predicting worse clinical outcomes, as indicated by increased PaCO 2 value and mortality.
The integration of genetic profiles, molecular markers, and AI-driven predictive models represents a strong trend toward personalized medicine, enabling clinicians to tailor treatment strategies that maximize organ preservation while ensuring oncologic safety.
To visualize the miR sequencing data analysis as a graph, significant upregulation was observed in the raw data reads for miR-155-5p in R-femur and O-osteocyte skeletal aging conditions, while a strong trend was seen in O-femurs (Fig. 3 B).
17 While higher numbers in the second and fourth quarters could indicate the role of fatigue within each half (as opposed to cumulative fatigue over the course of the match), one-third of injuries occurred in the first 5 minutes and more than 50% in the first 10 minutes of a player's effective playing time (when correcting for substitutions), with a strong trend showing fewer injuries as the minutes of the match increased.
When recounted to take into account what the respondents actually said ( Figure 2 ), a strong trend emerges showing that whereas White American respondents strongly preferred autonomy, Mexican respondents strongly preferred paternalism.
Once this initial environmental learning curve is accounted for, there does not appear to be a strong trend in the error across periods.
Another retrospective study on the treatment of 32 histological or radiological UIP-CTD patients with MMF found a strong trend of a decline before treatment and a stabilization after MMF [ 61 ].
Discussion For PF-06804103, there was in general a strong trend for a dose–response relationship for both safety and efficacy.