“a strong trend”

[ 24 ] This trial was terminated early because of a strong trend of decreased survival in patients treated with epoprostenol.

The increase in activity with 5 μM of FKBP12 was less than with 0.2 or 1.0 μM of FKBP12, and there was a strong trend toward reduced activation with 1.0 and 5 μM of FKBP12 compared with 5 nM and 0.2 μM of FKBP12.

There was also a significant main effect of treatment group on proximity to the platform with Tukey post-hoc tests revealing a strong trend for an impairment in the Tg-control group relative to the WT-control group, and a significant enhancement of performance back to WT levels for the Tg-sAPPα group, compared to the Tg-control group (Fig. 2c, d ).

In line with previous research, age at the time of breast cancer diagnosis was found to show a strong trend for predicting emotional vulnerability in women, with a younger age inferring higher levels of emotional vulnerability.

Introduction Development of point-of-care (POC) diagnostic medical devices has been a strong trend in recent years.

Currently, there is a strong trend in Australian mental health policy to focus on ‘broader, looser, and more benign’ concepts of mental health in the population, which has resulted in the neglect of public sector adult mental health services that care for people with severe mental illness. 8 , 9 The rise in climate-related anxiety in the community may accentuate this trend with governmental attention being diverted further away from severe mental illness.

In bladder cancer specimens, there was a strong trend to correlate between AR positivity and chemoresistance.

In contrast, Pax6os1 KO female (but not male) mice under HFD displayed a tendency toward reduced body weight ( Figure 3 F) and significantly lower circulating glucose at 30 min ( p = 0.041) during the IPGTT, with a strong trend toward a lower AUC during the experiment (WT: 1212 ± 169 a.u. vs.

When non-hypertensive and hypertensive participants were analyzed separately, non-hypertensive participants with PD showed a strong trend to have higher SBP than no PD ( Fig. 1 B), and hypertensive participants with PD showed significantly higher SBP than no PD ( Fig. 1 C).

Although no significant drug-by-group interactions were found, the effects of GSK598809 appeared to be largely driven by effects within the abstinent drug-dependent groups rather than controls (especially within the DRD3-rich VP where a strong trend to an interaction was observed).

A strong positive correlation between time and the DIORs indicates a strong trend, which we would expect to occur when approaching a tipping a point [ 12 ]. 2.4 .

Regarding the negative perturbation, we observe a strong trend that as supine collapse force decreases, the difference between supine and 16° collapse force decreases to approach zero.

By the end of phase 3 training, there was no significant difference in accuracy based on age group assessed by two-tailed, unpaired t -test [t = 0.594, p = 0.56], and there was not a significant effect of age on reinforcers earned at the end of training [t = 2.06, p = 0.061]; though there was a strong trend towards adults earning more reinforcers, potentially indicating greater motivation to perform the task.

A more recent smaller trial reported improved hemodynamics and a strong trend towards lower need for intubation by administration of caffeine within 2 h after birth [ 30 ].

Effects of pentoxifylline on serum cytokines As pointed out above, the serum cytokine levels presented in Table 2 , demonstrate that patients treated with PTX showed a strong trend toward an increase in IL-10, an anti-inflammatory cytokine, suggesting a favorable effect of the drug in modulating the inflammatory mechanisms present in the chronic phase of the disease.

There is a strong trend in nature to make the maximum use of finite resources; saving operational energy allows an organism to allocate more energy to reproduction.

A strong trend of decline, already described for sperm concentration from 113 × 10 6 /mL in 1940 to 66 × 10 6 /mL in 1990 [ 12 ], is observed for testosterone levels [ 13 ].

There is a strong trend toward increased soluble Aβ 1–40 in lysates of FXS brain samples ( Figure 6D ) while AβPP/AβPPα levels are reciprocally decreased ( Figure 6C ) in both the neocortex and hippocampus.

A strong trend towards a higher rate of differential expression for genes with longer transcripts is evident.

A strong trend between baseline glucocorticoid dosage categories (none, <7.5, or ≥7.5 mg/day) and each yearly time point was not identified.

As expected, we observed a strong trend toward reduced hepatic triglyceride levels in the HFD-fed Pde9a −/− mice ( Fig. 5 I ), with minor differences in fatty acid composition between genotypes ( Supplementary Table 3 ).

Therefore, due to such problems, nowadays, there is a strong trend towards replacing LLE by SPE.

Furthermore, our baseline contingency analyses revealed significantly greater use of alcohol and sedatives, and a strong trend toward increased stimulant use, among participants with ASRS ≥ 14.

also found significantly decreased PDH protein levels and a strong trend to increased pyruvate levels in the cerebella of 1-week old Npc1 -/- mice [71] .

In the Th2 comparative AHC analysis, for successively more restrictive subsets of the DeepRNA-Reg prediction set based on a cut-off for the DBE percentile, there is a strong trend of greater enrichment of seed binding sequence motifs for miRNAs 23, 24, and 27 ( Figure 3(D) ).