“a strong trend”

Hyperaemic flow velocity similarly diminished from 39.4 ± 22.4 to 26.7 ± 18.8 cm/s, demonstrating a strong trend.

The FDA recently expanded its indication for use in the pre-chemotherapy setting after it elicited significant delays in disease progression and a strong trend for increased overall survival in phase III studies.

However, there is a strong trend where more and more countries tend to use IGRAs rather than the TST.

Further analysis of markers of iron metabolism/ferroptosis in TBCP-1 tumours revealed increased levels of ferritin ( p < 0.05) and a strong trend towards decreased ferroportin-1.

When the extracted events are broken up by publication year, a strong trend for increasing number of citations containing gene/protein mentions and events is visible, with 25% of citations from the last 10 years containing at least one event ( Fig. 2 ).

Over the years, a strong trend towards more NOACs (14% in 2014 to 67% in 2019) and less triple therapy (62% in 2016 to 17% in 2019) was seen.

Interestingly, however, when comparing only the high alpha trials in which the phosphene was seen versus those in which it was not seen, a strong trend in frontal areas is revealed.

After adjustment for extracranial ultrasonographic findings and heart failure, there was still a strong trend (HR 3.13, 95% CI 0.94 to 10.49).

Interestingly, the percentages of the KLRG1+ NK cells and the MFI of the receptor showed a strong trend to increase in both types of mice in the lung compared to the spleen, although TAP1-KO NK cells still lagged behind wildtype for both of the parameters.

Moreover, there is a strong trend towards early diagnosis in dementia, which may increase the period during which care for patients with dementia will be asked for [3] .

The HF diet supplemented with berries resulted in a strong trend of higher total OTU richness and significantly increased the relative abundance of Akkermansia muciniphila , which has been linked to protective effects on cognitive decline.

Consequently, the subgroup analysis with the propensity score method revealed that afatinib had a strong trend of prolonged TD-TKI and OS over osimertinib in patients with the L858R mutation and without brain metastasis.

A strong trend is that the larger the initial burned area, the smaller the ultimate ischemic area.

However, there was a strong trend towards decreased IL-12 p40 levels in the spleens of LIF-treated rats compared to PBS-treated and sham rats (Fig. 4a ).

The EMERALD-1 trial showed that the addition of durvalumab (anti-PD-L1) and bevacizumab to TACE significantly extended progression-free survival compared with TACE alone (15.0 versus 8.2 months; HR 0.77, p = 0.032), successfully meeting the primary endpoint and demonstrating a strong trend toward overall survival improvement [ 93 ].

A strong trend was also noted toward improved 5-year survival among the group with ideal and adequate implants as opposed to unacceptable implants (60% vs. 40%).

[ 98 ], based on the NHANES III population, a strong trend was noted in which lower bone mineral density (BMD) as determined by dual energy X-ray absorptiometry (DEXA) was strongly associated with reduced creatinine clearance as estimate by the Cockcroft-Gault (CCr) equation.

However, we did observe a strong trend.

Due to low cellular abundance and a strong trend toward prognostic significance in the first analysis, two additional sections from all tumor samples were immunostained for CD20.

To reduce these bioethical problems, there is a strong trend to apply the “3 Rs” rule in experiments that involve animal use, which are: reduce the numbers of animals; refine the protocols to increase animal comfort and reduce pain; replace animals for other models that do not have bioethical problems associated [ 1 ].

We did observe, however, a strong trend toward lower membrane potential ( Figure S5 Q), higher input resistance ( Figure S5 R), and increased number of action potentials ( Figure S5 S) in CA2 PCs from Ccp1 cKO mice, as well as a tendency for a higher firing rate in response to current injection ( Figure S5 M).

At this time point, CART3-mCALR cell-treated mice exhibited a significant reduction in tumor burden compared with mock-treated animals, achieving complete tumor clearance in one mouse and demonstrating a strong trend toward increased infiltration of human T lymphocytes in both the spleen and bone marrow ( figure 3D ).

In contrast, lung metastases grew slowest in mice treated with SAR405, with a strong trend toward reduced endpoint tumor burden in mice treated with SAR405 alone as compared to MBC-613, and the addition of SAR405 to MCB-613 restored efficacy to near levels observed for single-agent SAR405 ( Fig. 6 A and B ).

These immunoblotting data indicate that the incubated cocaine-craving observed under the present self-administration procedures is associated with a strong trend towards a PL-selective reduction in mGlu1 and mGlu5 expression and that acute, oral, dosing with 1.0 mg/kg everolimus is sufficient to reverse these neuroadaptations within the PL and to augment mGlu1 dimer expression also within the IL.

We also observed a strong trend toward the collection of plant‐related quests by the students (Figure 3c,d ).