Although spebrutinib did not demonstrate efficacy in RA, it displayed a strong trend towards improvement in RA clinical efficacy measures as well as a reduction in circulating bone resorption biomarkers, near complete BTK coverage, and a significant reduction in circulating transitional B cells and an increase in naive cells.
Notably, in a dose-finding and production performance study conducted by our research team under identical heat stress conditions, supplementation with 50 mg/kg PEO not only showed a strong trend toward increased average daily dry matter intake (ADMI) but also significantly improved the average daily gain (ADG) in beef cattle [ 13 ].
4 d) were significantly improved with passage 3 cells only, although bacterial clearance exhibited a strong trend at all hMSC passages.
Some of the North Pond basalts, which were incubated for a much longer period of time, showed significant incorporation of 13 C into organic matter over time, while others did not exhibit a strong trend ( Figure 2B ).
As the oceans have warmed, the solubility of gases has decreased, resulting in a strong trend in declining dissolved oxygen content – a process known as ocean deoxygenation (Canadell et al., 2021 ).
40 Another study, on a far larger sample base of around 470 cancer patients, found no significant difference with regard to LBM after 8 weeks however a strong trend in the direction of an increase in LBM as measured by both bio‐impedance and skin‐fold measurements. 22 In summary, the effect of the combination of HMB, arginine, and glutamine on weight gain should be investigated in further studies on cancer patients investigating time periods of several months.
Affluent Western societies show a strong trend in the transition towards a more plant-based diet [ 35 ].
In this study, patient-based analyses comparing coronary CTA versus ICA for the detection of significant CAV (> 50%) showed a mean weighted sensitivity of 94%, specificity of 92%, negative predictive value (NPV) of 99%, positive predictive value of 67%, and diagnostic accuracy of 94%, with a strong trend toward improved sensitivity and negative predictive value with 64-slice compared with 16-slice coronary CTA [ 25 ••].
Examining confocal sections of these hearts, we measured intracardiac myocardial density as the area fraction occupied by cardiomyocytes within the outer third of the heart, and observed a strong trend towards reduced trabecular area in juvenile mutants and a significant reduction in adult mutants (Fig. 3 C–E).
Median progression-free survival (PFS) was longer on XVd versus Vd in patients with 1 prior line ( P = 0.0148) or 2–3 prior lines ( P = 0.0295), lenalidomide-naïve ( P = 0.0150) or lenalidomide-treated ( P = 0.0177) patients, and PI-naïve patients ( P = 0.0003), with a strong trend in PI-treated patients.
There was a strong trend for GPT‐driven ratings to be higher than the corresponding ground truth data.
Our findings support this, showing a strong trend towards significance when examining the influence of childhood trauma on leptin levels (more trauma leading to higher levels of leptin).
Differences in concurrency were noted based on sex, urban/rural status and median household incomes, with the prevalence of concurrency being highest among the lowest incomes, as well as a strong trend in age ( table 1 , figure 2 ).
The primary endpoint was percentage diameter stenosis in-segment/in-balloon, and stenosis rates were significantly lower in the DES group; there was also a strong trend toward better clinical outcome with tree times as many MACE in the DEB group than in the DES group, mainly driven by a difference in TLR events [ 48 ].
Though not significant, both nitrite ( P = 0.15) and CO ( P = 0.08) treatment showed a strong trend toward preserving aconitase activity (Figure 6 B), consistent with the prevention of oxidative stress.
We did not investigate ceramide, but both a strong trend for 5 and a statistically significant 18 decrease in total ceramide levels have been reported in sporadic PD anterior cingulate cortex, 5 suggesting that changes in sphingolipid metabolism may occur in PD.
Among non-participants, abstinence also increased from 7% at initial contact up to 17% at 12 months post-surgery ( p = 0.3). Comparing abstinence among participants versus non-participants, while there was a strong trend for higher 12-month abstinence of 42% among participants versus 17% among non-participants, this was not statistically significant ( p = 0.11).
The resampling test showed a strong trend towards rejecting highly expressed genes ( Table 2 ) and there is striking similarity across genomes in what genes display a significantly increased CAI values, or codon adaptation.
Furthermore, in silico cell deconvolution using the ImmuCC algorithm ( 17 ) predicted a strong trend toward increased CD8 + T cells in tumors from the AFP immunized mice ( Supplemental Figure 6 , E and F), in line with the flow cytometry and IHC data ( Supplemental Figure 1 and Figure 2, D–F ).
There was a strong trend for improving the live birth rate in this group of older women.
Notably, there was a strong trend toward improved PFS in patients with brain metastases.
From 1994 to 2018, global publications in the field exhibited a strong trend for exponential growth (Figure 1c ). 3.1.3.
In contrast, 3 prospective studies showed a strong trend toward lower rates of acute rejection in the HMP group, although this did not reach significance.
Eventually, the system could be implemented synergistically with other recent advancements in the field of medical device engineering, where there is a strong trend towards non-invasive [ 27 , 28 , 29 , 30 ] or totally contactless [ 31 , 32 , 33 , 34 , 35 , 36 , 37 ] measurement.
There is a strong trend for signatures of younger researchers and those in the lower professional ranks to appear in the first position ( junior signing pattern ), while more veteran or highly-ranked ones, who tend to play supervisory functions in research, are proportionally more likely to sign in the last position ( senior signing pattern ).