“a small trend”

Properties of the apo/holo pairs The median resolution across our dataset was 1.6 Å with a small trend towards improved (higher) resolution in the apo structure (0.01 Å, median improvement [holo-apo]; p=3.8 × 10 –20 , Wilcoxon signed-rank test; Figure 1—figure supplement 3A and B ).

For the KEGG 3+DB signalling pathways network betweenness centrality – a measure of the difference between the node with the highest betweenness centrality (the node on the most shortest paths) to all other nodes in the network – we did see a small trend towards pathway networks having lower betweenness centrality (p<0.0001 (WNT pathway) to p<0.837 (VEGF pathway).

Before the pandemic, there was a small trend of increased prescribing (incidence rate ratio [IRR] per period 1.002; 95% confidence interval [95CI] 1.001–1.002; p<0.001), with a change in level (immediate increase) at the pandemic date (relative increase in IRR 1.674; 95CI 1.206–2.322; p = 0.002).

However, whereas overexpression of SNRPN-WT showed a small trend in reducing neuronal maturation (Neurite length: One-Way ANOVA: F[2,45] = 6.29, p = 0.003; SNRPN-WT versus empty vector control: p = 0.0627, Tukey’s multiple comparison test; Arborization: One-Way ANOVA: F[2,45] = 5.66, p = 0.006; SNRPN-WT versus empty vector control: p = 0.44, Tukey’s multiple com

S9 B , Top ; unpaired t test; q > 0.1, FDR correction of 1,488 comparisons), although there was a small trend of increased medium gamma power on correct trials at false goal zone ( P = 0.032, t 13 = −2.403, at 66.41 Hz, paired t test; q > 0.1, FDR correction of 1,488 comparisons).

There was a low bias in the number of SCC entrances identified between SCC-Maps and EAM screening maps, with a small trend towards a SCC subidentification of SCC-Maps compared with EAM screening maps (Pearson's R = 0.48, p =0.033), which is in concordance with the findings of Table 2 .

Analysis of the MTHFR A1298C frequency data obtained in this study showed that the heterozygotes ( AC ) were overrepresented in MS patients (67.8% versus 45.7%, P= 0.00) and a small trend for a higher frequency of the homozygous mutant genotype ( CC ) was observed in controls (11.8% versus 2.8%, P= 0.04).

The intensity of this band (relative to β actin) did not differ significantly between resting and activated cells, although there was a small trend for it to increase ( Fig. 5 C ; P > 0.05).

Further F contrasts confirmed a significant facilitation for the contralateral TMS compared with no TMS at both time windows (both P < 0.01) and a small trend of marginal significance ( P = 0.05) for facilitation with ipsilateral TMS compared with no TMS in the 150-ms time window.

In comparison, the consistent low belongingness condition showed a large increase in desire to quit from Phase One to Phase Two, t (13) = −2.70, p = 0.02, d = −0.75, while the control condition showed a small trend toward decreasing desire to quit, t (12) = 2.21, p = 0.05, d = 0.19.

The fatigue–tingling symptom pair did not show any significant differences, although a small trend between RRMS and SPMS could be observed (0.55 in RRMS versus 0.43 in PPMS, p = 0.056, Figure 6 B). 4.

balteata beetles did not lead to an increase in trichome density in the third leaf for domesticated varieties (Tukey test: P = 0.3344), but there is a small trend of induction in wild populations after the beetles feeding (Tukey test: P = 0.0575) (Fig. 5 a).

Despite a small trend for (a), the threshold was not met ( P = 0·058).

A study observed a small trend for higher levels of serum folate in the group of patients with methylated tumours, compared to those with unmethylated tumours ( P = .06); moreover it was observed a trend for association between serum folate/vitamin B12 levels and gene promoter methylation: higher serum folate/vitamin B12 levels were strongly associated with promoter methylation of P16 and had an association (trend) with promoter methylation of MLH1 and MLH2 genes [ 127 ].

The mIPSC frequency showed a small trend of decrease (p = 0.06) in the cKO neurons.

In contrast, feeding a HFD to DUhTP mice did not result in significant changes in fat deposition with abdominal adipose tissue weight reaching a small trend towards increased levels (p = 0.06) in the n-3 HFD-fed animals compared to the standard chow-fed group (Table 2 ).

For the mental component score there were only subtle differences between disease activity states, but still a small trend toward better outcomes with lower disease activity (mental component score: SDAI-REM: 49.9 ± 11.1; LDA, 47.9 ± 12.3; MDA/HDA: 46.6 ± 12.3; P = 0.06).

Both cross-tissue and within-tissue expression-based datasets were significantly enriched for ChIP-seq overlap (cross-tissue enrichment statistic = 0.024, p < 2x10 -4 ; within-tissue enrichment statistic = 0.088, p = 2x10 -4 ), and cross-tissue expression-based TF-eQTLs showed a small trend of motif matching enrichment (enrichment statistic = 0.002, p = 0.06) (Figs 3A and S13 ).

First, subjects might have accommodated during the objective refraction, but there was only a small trend that younger participants showed higher differences than older participants (R = −0.2, p = 0.06).

As shown in Figure 11D–F , Nezavist alone did not alter the number of c‐Fos‐positive cells in either NTS subregion, although there was a small trend for suppression of c‐Fos‐positive cells in the anterior NTS (post hoc tests; anterior vehicle‐treated, Nezavist—placebo: p = 0.0612; posterior, vehicle‐treated, Nezavist—placebo: p = 0.45).

The main effect of gender showed a small trend, with women reporting higher discomfort than men, F(1, 113) = 3.56, p = 0.062, ηp 2 = 0.031 (women: M = 21.64; men: M = 13.72).

At 24 months, a small trend favouring mean thickness was observed in the central condyle (volume: licofelone: -35.1 ± 60.9, naproxen: -46.3 ± 40.0, p = 0.062; mean thickness: licofelone: -0.047 ± 0.096 naproxen: -0.067 ± 0.072, p = 0.040), whereas at 6 and 12 months both methods provided similar findings.

There was a small trend for the interaction effect ( p = 0.063; η 2 = 0.039), non-significant group main effect ( p = 0.827; η 2 = 0.002), and a significant time main effect ( p < 0.001; η 2 = 0.328) on the BDNF concentration.

Finally, comparisons between Day 28 and Day 1 revealed a small trend for higher baseline REE in CAF at 0 min ( p = 0.064, d = 0.28).

A small trend toward lower SPI was registered in the SPI-guided group during incision and pneumoperitoneum ( p = 0.066 and 0.069, respectively), despite SPI values being comparable across groups.