“a significant trend”

As these advanced and expensive technologies have evolved and become more available, however, I have noted a significant trend away from bedside basics.

In terms of the types of antidepressants used during ECT, TCAs showed a steady decline, but other medications such as SSRIs, SNRIs, and MAOi did not reveal a significant trend.

Earlier studies revealed a low incidence in general ranging between 0.2 and 0.76 cases/1000 hospital discharges, [ 25 – 28 ] while more recent studies revealed a higher incidence with a median rate of 1.65 per 1,000 hospital discharges per year with a significant trend towards higher rates over time [ 29 , 30 ].

This appears to be a persistent effect, as a significant trend toward lower HDL levels with increasing parity has been shown in old age (Humphries et al ., 2001 ).

In contrast, cardiac catheterization increased significantly during the pre-COVID period (2012–2019) but did not demonstrate a significant trend when the 2020–2022 period was included, suggesting that interventional cardiology services were expanding prior to 2020 but experienced disruption or plateau during the late period.

In the quarter following easing of restrictions, there was a significant trend towards earlier stage (cStage I/II) disease.

The decentralisation of health systems in low and middle income contexts has been a significant trend in health systems reorganisation for forty years.

Figure 14 clearly shows a significant trend in the GRU network’s reconstruction of acceleration data: the data tends to converge towards the mean value of the entire dataset.

The innovation of exercise-centered lifestyle intervention therapy may become a significant trend in the future.

Slattery et al (2013) examined the dietary oxidative balance and observed a significant trend toward reduced breast cancer risk with a higher dietary oxidative balance. 18 Xu et al (2025) analyzed US cancer survivors and found that a higher OBS strongly predicted lower all-cause and cancer-specific mortality, 19 suggesting that even after diagnosis, better oxidative balance confers a survival advantage.

This finding was also supported by unadjusted analyses of the individual segmentations, which revealed a significant trend toward an increase in the number and total volume of brain contusions with a worse outcome category (Table 3 ).

Moreover, a significant trend toward shorter LOS over time was confirmed.

In California, we also found a significant trend of northward and altitudinal expansion of areas suitable for C. capitata establishment.

After accounting for potential confounders, we observed a significant trend across the tertiles of dietary intake for three DASH diet indices, Mellen’s, Fung’s and Günther’s, with P-trend values of 0.01, 0.002, and 0.03, respectively.

However, “aa” genotype polymorphisms in ApaI SNP and “a” allele showed a significant trend towards a lower frequency among patients with CL compared to control indicating that this association could represent a protective effect against CL.

Multimodal sensing Multifunctional sensing represents a significant trend in sensor development, offering potential benefits such as reduced spatial requirements, simplified integrated systems, and enhanced information coupling.

Furthermore, we observed a significant trend towards a lower risk of prevalent IHD across the groups (all P for trend < 0.001).

A significant trend observed in the data of this study is represented by the highest level of volatile compounds in 170 DAF fruits in both considered areas and a steady decrease during the progression of fruit ripening.

A significant trend aimed at improving information flows in supply chains is the digital transformation observed for several years.

Long-term changes in crop phenology (observer network western Germany) The PVTT from emergence to heading (PVTT heading ) calculated from the observations for western Germany showed similar trends, with a 15% smaller PVTT heading in the most recent years than before 1986, which did not show a significant trend (Fig. 2d ).

The same tests in the longitudinal direction did not show a significant trend for different locations.

All three cohort studies reported stronger associations between PM 2.5 and cardiovascular mortality among obese subjects and one reported a significant trend of increased risk with increased body mass index.

Discussion Contemporary analyses of a homogeneous ethnic and socioeconomic group of children and adults at a single reference center in a low-middle income country over a fifteen-year period provide evidence for a significant trend per month of the ALL diagnosis, with the highest number of cases diagnosed in March, followed by October.

When comparing the younger (6–9 years) to the older (10–12 years) children, a significant trend towards a reduction in overweight including obesity could be seen in the younger, but not the older, children (OR = 0.984 (0.972–0.996) for 6–9 year old children and OR = 0.991 (0.977–1.005) for 10–12 year old children).

Over the past few decades, a significant trend has been the proliferation of artificial blue light sources and a marked increase in human exposure to blue light at night.