“a significant trend”

Furthermore, the good P/S mitochondrial pattern was preserved in a percentage comparable to the controls, although the quantification data indicated a significant trend towards loss of viability.

The result of the trend analysis was P-trend < 0.001, which indicated that there was a significant trend among the three LE8-score groups, that is, there was an obvious positive correlation trend between the decrease in the LE8 score and the existing risk of CHD.

The critical values of statistical test Z ∝ /2 = ± 1.28, ± 1.96, and ± 2.58; *+** and *** denote the existence of a significant trend at confidence levels of 90%, 95%, and 99%, respectively.

A significant trend was observed in the shift from traditional endoscopic interventions to pharmacological therapies, particularly highlighting the successful use of sirolimus in treating colonic angioectasia.

18 In the present study, evaluation of serum CA-125 levels showed that the mean levels of this marker in women with pelvic endometriosis were higher than in normal women, thus confirming data from other authors 19 – 21 When calculating the correlation between CA-125 levels in serum and peritoneal fluid and the disease staging we noted a significant trend towards a linear increase in this marker with disease severity.

The previously published post hoc analysis of the COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) trial of 2287 subjects showed that for each end point (fatal or nonfatal myocardial infarction, heart failure, percutaneous coronary intervention), there was a significant trend for increasing risk as the metabolic risk factor number increased. 28 However, in the stratified multivariable analysis by age, we found that even 2 risk factors clustering was associated with a higher risk in the middle‐age group; however, more metabolic risk factors clustering was not significantly associated with greater risk of LVDD for the elderly participants.

Serum ALT and AST, but not plasma M30 showed a significant trend with increasing grades of ballooning and lobular inflammation.

Given the absence of a significant trend in alcohol use patterns, we conducted an additional exploratory analysis to assess changes in the prevalence of at-risk drinkers, based on the AUDIT-C score [ 47 ].

Glycerol content showed a significant trend of initially decreasing and then increasing in all acclimated groups.

Thus, achieving accurate and efficient automated grade assessment of TB while alleviating pathologists’ workloads is a significant trend in the current development process of clinicopathological diagnostics.

A United States study using the Nationwide Inpatient Sample Database from 2006 to 2018 showed a yearly mortality rate of 13.1–13.7% and did not demonstrate a significant trend in mortality reduction [ 6 ].

Additionally, there was a significant trend of decreasing obesity prevalence with decreasing education.

The Cochran-Armitage trend test indicated a significant trend regarding the duration of exclusive breastfeeding and frequency of antibiotic treatment during the child’s first year across subgroups (P for trend < 0.01).

3.1 International Collaboration and Population Characteristics Clinical trials of the use of PARP inhibitors for the treatment of prostate cancer have demonstrated a significant trend toward international collaboration (Figure 2A ).

In the past few decades, there was a significant trend for improved survival for both adenocarcinoma and squamous cell carcinoma of the cervix, but no detectable improvement for small cell carcinoma of the cervix [ 3 ].

There was also a significant trend toward lower socioeconomic status over time, as reflected by the lower percentage of patients in income quartiles 3 and 4 (overall HF: 45.5% in 2008 to 43.9% in 2017; HFpEF: 50.6% in 2008 to 47.1% in 2017; HFrEF: 43.5% in 2008 to 42.2% in 2017; P <0.001 for all).

To test for a significant trend in nest numbers over time we used a linear regression model of the mean number of nests observed per night per beach against years since 1991 (i.e. # nests ~ f (beach + year + beach × year), using the software R [ 29 ].

We observed a significant trend toward reduced AKI with NO use.

There was a significant trend wherein the highest plus strand peak was 30–31 bp from the highest minus strand peak for both plasmid DNA that contained (pCR7) or lacked (pControl) the CRISPR array (Figure 2B and C ).

Before NVBP, neither drug exhibited a significant trend in utilisation or expenditure.

Given that hepatomegaly can be caused by various factors, including hepatic sinusoidal dilatation, high venous pressure and congestion, fat accumulation in liver cells and fibrosis, and glycogen distention of liver cells, early diagnosis, and identification of the primary causes of hepatomegaly are critical for disease treatment.[ 25 26 ] This study also found a significant trend for a larger liver size from mild to severe grade of fatty liver.

Transcriptomic analysis of 641 NSCLC patient samples from the TCGA database [ 45 ] revealed a significant trend toward reduced overall survival in patients with high GHR expression.

In another vein, with increasing the loadings of either microcrystalline cellulose or TiO 2 fillers, there is a significant trend in the apparent density of RPUF composites in comparison to alkaline lignin, as depicted in Figure 3 a.

Examining the CMI tertiles, a significant trend was observed across all models.

Incidence trends in men, mortality in men, and mortality in women were not statistically significant, while a significant trend was observed in incidence in women (annual percent change -1.5; 95% confidence interval -2.3 to -0.6).