“a significant trend”

The peak of cortisol after ACTH stimulation test had a significant trend to decrease during Lenvatinib treatment (p= 0.0011) ( Figure 1 ).

If syndromal, multiple and chromosomal abnormalities were grouped together under the label “extended,” their proportion compared to unique malformations yield significant differences ( P = 0.014) according to parental mutation status and a significant trend was objectivized ( P = 0.0011) from the first to the fourth group (Table 2 ): Children of deleterious mutation carriers had a 10‐fold risk of “extended” malformation in comparison to the control group.

There was a significant trend towards a better resolution of AM depth in the RAM condition (minimal modulations thresholds: −27.4 ± 6.5 compared to −24.5 ± 6.1, P = 0.0012, mean ± SD; Wilcoxon paired test, two tailed), i.e. with a steeply rising stimulus onset already somewhat shallower modulations led to a significant locking of spikes to the stimulus envelope; the corresponding differences are, however, biologically probably not very relevant: minimal modulations depths of 4.3% (RAM) and 5.9% (SAM).

A significant trend toward the peritumoral TILs pattern was observed, demonstrating higher PD-1 cell counts ( P = 0.0012).

Furthermore, a significant trend also revealed poorer OS in the high-risk group compared to the low-risk group (log-rank P = 0.0012, Fig. 4G ), as well as in the GSE9891 validation cohort (log-rank P = 0.014, Fig. 4H ).

Dimethyl sulfone showed a significant trend ( p = 0.00139).

RESULTS Hypothesis 1: Age‐based terms describing older adults are associated with more negative stereotyping compared to role‐based terms across the pandemic As hypothesized, age‐based framing from October 2019 to May 2020 was associated with more negativity as shown by a significant trend ( β = −0.023, p = 0.00148), compared to the trend for familial role‐based framing which did not reach significance ( β = −0.00343, p = 0.532).

When this result was analyzed according to PESI class, a significant trend toward increased mortality with a higher class was detected ( p =0.0016), with 0% in class I, 10.3% in class II, 9.1% in class III, 0% in class IV, and 50% in class V.

We observed a significant trend toward using a higher sun protection factor (SPF) in melanoma patients compared with at-risk patients (SPF 50+: 48% [n=60] vs. 26% [n=37]; p=0.0016).

Aspirin administration was associated with a significant reduction of PD‐related complications < 32 weeks, with a significant trend for a simultaneous increase of PD‐related complications ≥ 32 weeks (test for trend, p value = 0.0018, Table 1 , Figure S5 ).

Regarding the history of STI in the year prior to suspicion, those who experienced an infection had a 1.55 times higher risk of being a case (95% CI 1.13 to 2.12) with a significant trend ( χ 1 2 = 9.74, p=0.0018) in the ORs.

Moreover, although the model adjusting for age, gender, ethnicity, and total energy intake suggested a significant trend between lifelong milk exposure and cataract extraction history ( p =0.002), none of the individual groups were significantly different from the high exposure group ( p > 0.01, Table 3 ).

There was also a significant trend in reducing plasma TAG (-50%) in G (Ala12) carriers as the PUFA:SFA ratio increased from 0.34 to 0.65 ( p = 0.002).

The seven-category ordinal scale in the prone group indicated a significant trend relationship with time course ( p = 0.002), although this association was not observed in the non-prone group ( p = 0.102).

The meta-analysis showed a significant trend towards the experimental group compared to the control group (−0.71, 95% CI [-1.15 to −0.27], p = 0.002).

A significant trend was seen for reason for use with younger athletes using cannabis more for recreational ( p = 0.002) and both THC and CBD for medical and recreational reasons (p = 0.009), while older athletes used cannabis for medical purposes (p < 0.001).

In addition, we found that patients with high levels of C9orf86 expression showed a significant trend towards worse survival compared to patients with low C9orf86 expression (P = 0.002).

Over the years it was observed a significant trend to reduction in white women mortality rates [B1 = (−)0.10; p = 0.002], and a significant trend to increase in black women mortality rates [B1 = (+)0.07; p = 0.010].

There was a significant trend to having fewer patients in the advanced T-stage (p = 0.002) and N + groups (p = 0.01) within the perioperative chemotherapy group, despite randomization.

This interaction revealed a significant trend for increased performance with reading age after regular primes in children with TD, trend = 1.26, SE = 0.40, p = 0.002, z -ratio = 3.13, r = 0.48, 95% CI around effect size [0.20, 0.66], but not after irregular primes in children with TD ( p = 0.28) and not in children with DLD after regular ( p = 0.35) or irregular ( p = 0.10) primes.

For acetic acid derivatives there was a significant trend toward decreasing association with increasing cumulative dose ( p = 0.002).

A significant trend where individuals with higher BMI were more likely to have low testosterone was identified ( p = 0.002) (Table 2 ), and this association was evident when assessing both primary ( p = 0.032) and secondary ( p = 0.028) low total serum testosterone (Table 3 ).

Figure 1 shows a significant trend toward lower accuracy on this measure as DTN performance declined ( P =0.002).

There was a significant trend of increase in global RPC VD after SO removal ( F = 5.417, P = 0.002) (Fig. 2 ).

Mortality following oesophagectomy showed a significant trend ( χ 2 =9.5, df=1, P =0.002 at 30 days; and 12.6, P =0.0004 at 90 days), with standardised death rates rising with increasing levels of social deprivation.