“a significant trend”

The significance level was set at p < 0.05, with 0.05 < p < 0.10 being considered a significant trend and used as a reference to determine the overall trend.

These risks are particularly concerning for patients with glomerular filtration rates below 30 mL/min/1.73 m 2 , with a significant trend at 30–44 mL/min/1.73 m 2 [ 32 ].

In terms of population characteristics, age, gender, histology, clinical stage, first-line immunotherapy and therapeutic Regimen did not show a significant trend toward primary drug resistance (Table 2 , Table S1, S2, S3).

In the immune-positive group, the median RFS had not yet been reached, while the immune-negative group had an RFS of 13.4 months, with a significant trend difference ( 24 ).

Compared with Q1, the ORs were 1.18 (95% CI: 0.83–1.50) for Q2, 1.32 (95% CI: 1.11–1.53) for Q3, and 1.47 (95% CI: 1.15–1.79) for Q4; the OR per SD increase was 1.29 (95% CI: 1.20–1.38), with a significant trend across quartiles ( P for trend < .001).

The proportion of females was 59.8%, 65.3%, 68.4%, and 73.0%, respectively, with a significant trend of increase ( P for trend <0.001).

Overall, the 5hmC reads within these four signature genes showed a significant trend of co-localizing with histone modifications that mark enhancers and active expression (i.e., H3K4me1and H3K27ac), compared to repression markers (i.e., H3K27me3 and H3K9me3) (Fig. 3a ).

Age was stratified, with a significant trend toward older adults (most of the sample).

Although patients who were rehospitalized up to 6 months had significantly lower 6MWD on admission and discharge on univariate comparison, we could not find a significant trend of increase in rehospitalization with decreasing quartiles of 6MWD on admission (P for the trend 0.175) and discharge (P for the trend 0.077).

Neither was a significant excess risk nor was a significant trend observed for FA exposure (exposure versus no exposure), duration of exposure, cumulative or average intensity.

Limitation and future study This study focuses only on the Republic of Congo, with a significant trend in study variables due to data availability constraints.

A significant trend is the emergence of advanced sequence models: transformers, large language models (LLMs) architectures, and Generative Adversarial Networks (GANs) have been used in 18 studies (15.7%).

10 A study in the USA among adults aged ≥60 years has shown a significant trend for a higher proportion of obese individuals to be living with disability compared to their normal-weight counterparts in more recent years when data of the National Health and Nutrition Examination Survey (NHANES) in 1988–1994 (time 1) and 1999–2004 (time 2) were compared. 11 In this US study, compared to normal-weight individuals, obese people had a 1.78 times higher odds for functional impairment at time 1 but this increased to 2.75 at time 2.

o pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY issue-copyright-statement © BioMed Central Ltd., part of Springer Nature 2023 Introduction Population aging has emerged as a significant trend of social development at the global scale in recent years [ 1 – 3 ].

No other single covariates used in the analysis showed a significant trend on occupancy ( Table 5 ).

A multivariate model consisting of ISCR and the significant variables from the univariate analysis showed a significant trend for ISCR; however, the low sample size did not provide enough power for the model to be included in this study.

Myopia and high myopia prevalence appeared increased across the age range with a significant trend, but this contrasted with hyperopia prevalence.

Moreover, we confirm in a separate cohort a significant trend of increasing plasma CXCL9 when RhCMV + animals were stratified by effector CD8 + T cell proportions in blood, the canonical signature of chronic CMV.

A longitudinal study conducted in a Danish population [Monitoring Trends in Cardiovascular Disease (MONICA)], after adjustment for confounding factors, showed a significant trend between salt intake and an increased energy consumption from all macronutrients.

There was a significant trend for greater volume associated with decade of birth for white matter and hippocampal volumes and cortical surface area.

Similar associations were observed when the metabolomic signature was analyzed in quintiles (Q1–Q5), with a significant trend across categories (Supplementary Table 20 ).

We also found that regulated rivers are more likely to show a significant trend in river width than free‐flowing rivers (46% vs. 34%).

When the same cutoffs were applied to the validation set, one miRNA, miR-409-3p, remained significantly associated with NMIBC with a significant trend for increased risk in the tertiles with reduced expression for both discovery set ( P for trend = 0.013) and validation set ( P for trend = 0.019) (Table 2 ).

To address the challenge of data scarcity and improve generalization, a significant trend has emerged towards leveraging large-scale, multi-institutional datasets.

There was a significant trend in the expression of some genes in different organs (Fig. 6 A) 76 genes were expressed in at least one tissue, and MmWRKY56 was not expressed (COUNT < 0).