“a significant trend”

The Mantel–Haenszel test for trend revealed a significant trend in the prevalence of all food outlets across levels of deprivation, whereby prevalence of fast food and other unhealthy food increase with area deprivation.

In another vein, with increasing the loadings of either microcrystalline cellulose or TiO 2 fillers, there is a significant trend in the apparent density of RPUF composites in comparison to alkaline lignin, as depicted in Figure 3 a.

22 Concordantly, we previously reported a significant trend towards an increased PD‐L1 expression according to the smoking status (never, former and current smokers) within our study population. 6 In the context of single‐agent pembrolizumab, current/former smokers have already been confirmed to experience improved ORR and prolonged survival within th

HbA1c also showed a significant trend downward with increasing education.

Transcriptomic analysis of 641 NSCLC patient samples from the TCGA database [ 45 ] revealed a significant trend toward reduced overall survival in patients with high GHR expression.

A significant trend was observed at 12 weeks.

Given that hepatomegaly can be caused by various factors, including hepatic sinusoidal dilatation, high venous pressure and congestion, fat accumulation in liver cells and fibrosis, and glycogen distention of liver cells, early diagnosis, and identification of the primary causes of hepatomegaly are critical for disease treatment.[ 25 26 ] This study also found a significant trend for a larger liver size from mild to severe grade of fatty liver.

Notably, the incidence rate of new-onset T2D increased with increasing AIP, demonstrating a significant trend ( P-trend < 0.001).

During the multivariate analysis, OLGA stages III and IV were associated with an increased risk of gastric cancer [OR: 2.09 and p = 0.008 and OR 2.04 and p = 0.014, respectively], with this increase displaying a significant trend from OLGIM stages I to IV (OR: from 3.64 to 13.2).

A significant trend in reduction of peripheral artery disease (PAD) over the guideline versions was found, adjusted for age, sex and diabetes duration (odds ratio (OR) 0.70, 95% CI 0.51-0.97, p trend = 0.029) and for retinopathy in all models (OR = 0.52, 95% CI 0.37-0.73, p trend < 0.001).

Before NVBP, neither drug exhibited a significant trend in utilisation or expenditure.

There was a significant trend wherein the highest plus strand peak was 30–31 bp from the highest minus strand peak for both plasmid DNA that contained (pCR7) or lacked (pControl) the CRISPR array (Figure 2B and C ).

In the fully adjusted model (Model 3), compared with the lowest Quartile 1, the β coefficients (95% CI) for SII were 87.00 (2.84 to 171.16) in Quartile 3 and 197.85 (105.52 to 290.18) in Quartile 4, with a significant trend across ascending PRL quartiles ( p for trend = 1.55 × 10 -5 ).

We observed a significant trend toward reduced AKI with NO use.

However, there has been a significant trend towards the emergence of other species such as C . glabrata , C . krusei, and C . parapsilosis which ironically show more resistance to the first line antifungal treatments [ 6 ].

Previously, we demonstrated that PPARα had a significant trend of association between GG polymorphism, especially G allele, and elite soccer player. 25 Through this new approach, we realized that the polymorphism investigation could be a marker of the elite phenotype only if it’s associated each other.

To test for a significant trend in nest numbers over time we used a linear regression model of the mean number of nests observed per night per beach against years since 1991 (i.e. # nests ~ f (beach + year + beach × year), using the software R [ 29 ].

There was also a significant trend toward lower socioeconomic status over time, as reflected by the lower percentage of patients in income quartiles 3 and 4 (overall HF: 45.5% in 2008 to 43.9% in 2017; HFpEF: 50.6% in 2008 to 47.1% in 2017; HFrEF: 43.5% in 2008 to 42.2% in 2017; P <0.001 for all).

There was, however, a significant trend for increased evening cortisol within 12 h of seizures, which may become more pronounced with more accurate seizure capture.

In the past few decades, there was a significant trend for improved survival for both adenocarcinoma and squamous cell carcinoma of the cervix, but no detectable improvement for small cell carcinoma of the cervix [ 3 ].

3.1 International Collaboration and Population Characteristics Clinical trials of the use of PARP inhibitors for the treatment of prostate cancer have demonstrated a significant trend toward international collaboration (Figure 2A ).

Overall, when comparing baseline values of FG and BMI with those assessed at the latest follow up for the entire study cohort, our data showed a significant trend towards increasing FG and decreasing BMI.

Similar to the above maximal muscle strength results, groups with low-frequency band vibrations showed a significant trend toward a greater improvement in muscle imbalance.

In-hospital mortality among CUD patients followed a non-statistically significant trend from 0.7% to 1.1% from 2010 to 2014 (P trend < 0.137), but there were a significant trend increase from 2010 to 2014 for both LOS in days (P trend = 0.001) and total hospital charges (P trend < 0.001).

Discussion This trial found that a PHW intervention was associated with decreased virologic failure rates among patients on longer-term ART (≥96 weeks) with a significant trend of declining risk for virologic failures over time compared to the control arm.