Thus, the rise of small biopharmaceutical companies, recently known as “emerging biopharma” [ 11 ], in the development of new vaccine platforms was a significant trend in COVID-19 vaccine development [ 12 , 13 ].
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The gene encoding (S)-2-haloacid dehalogenase showed a significant trend to be missing in non-marine genomes ( Table 1 ).
S1 - 9 for the number of sites with a significant trend).
Among the countries that participated in SMART each year from 2016 to 2024, three (Argentina, Chile, and Panama) exhibited a significant trend of increasing susceptibility to ceftolozane/tazobactam ( Figure 4 A).
The result indicates that the annual precipitation has been decreasing in 71% of climatic stations and 43% of these stations showed a significant trend.
Beyond that, similar to European Union, the export trade also has a significant trend over time, whereas the import trade is not obvious.
Figure 4 illustrates the scatter plot of the Fisher-transformed insula–DMN connectivity values against HRV, further demonstrating the absence of a significant trend (with R 2 = 0.002). 4.
Participants in Q3 had an OR of 0.69 (95% CI: 0.49–0.97), and those in Q4 had an OR of 0.70 (95% CI: 0.47–1.05), with a significant trend across quartiles ( p for trend = 0.029). 4.
In recent years, there has been a significant trend towards delayed childbearing, with women in Western countries increasingly achieving their first pregnancy at older maternal ages ( Mathews and Hamilton, 2014 ).
The findings indicated a significant trend across vitamin D status groups.
Consistently, glycaemia did not show a significant trend and C-reactive protein showed a U-shaped relationship within the cumulative POPs score categories ( Fig. 3B ).
When comparing prescriptions of transdermal with oral preparations, however, we found a significant trend towards lower rates of prescribing with increasing deprivation for both oestrogens and progestogens.
suturalis shells from 22 separate populations, and showed a significant trend for sinistrals to be stouter.
A significant trend could only be extrapolated for age as an independent variable.
When focusing on multinucleated osteoclasts (>2 nuclei), no significant differences were observed between wild type and TTD mice although TTD cultures showed a significant trend towards a decline in multinucleated osteoclasts with aging ( Fig. 6E ).
In contrast, a significant trend towards an increased HIV-1 infection rate was observed in volunteers that had high pre-existing antibody titers against Ad5 (>200), compared to individuals with low pre-existing Ad5-specific titers (<200) [126] .
To determine whether a significant trend existed in the tumor expression of PD‐L1 or IDO1 between the GGO groups, we performed a Cochran–Armitage trend test.
For cycling and sports, neither deprived districts nor control districts showed a significant trend change.
We also displayed a significant trend of increased level of mesothelin with Duke's stage of plasma samples from stage A to D.
The results showed a significant trend toward higher validity for moderate to vigorous physical activity from the low to high fitness group as assessed by GPAQ and IPAQ-SF (low, intermediate and high fitness group: 0.06–0.21; 0.26–0.29; 0.40, respectively).
An investigation into the association between current smoking status and the incidence of AR revealed a significant trend of decreased AR occurrence among CC users.
A significant trend was observed between the frequency of forest walking and the crude prevalence of hypertension in both men (trend p =0.03) and women (trend p <0.001); the higher forest walking frequency groups had a higher prevalence of hypertension.
We found a significant trend to a higher frequency of poorly controlled asthma in children with eczema and rhinitis combined.
of 230 patients with candidemia.[ 22 ] The results showed a significant trend for increased mortality with progressive delays in the initiation of fluconazole therapy.
Only one of the analyzed characteristics of oak pollen seasons had a significant trend during the 16-year period of pollen monitoring (Table 1 ; Fig. 1 a).