“a significant trend”

The phase III TORCHLIGHT study ( 27 ) from China showed toripalimab + nab-paclitaxel treatment group significantly prolonged PFS benefit of mTNBC patients in PD-L1-positive (CPS ≥1) and ITT populations, and there was also a significant trend of OS benefit.

The Δ/Δ/Δ/Δ mutant showed a significant trend toward decreased viability by 6–8 h that was not observed for the wild-type control or complemented strains ( Fig 2A ).

Based on the screen two genes ATF3 and SPHK1, a significant trend distinction between the HIV and healthy samples was observed using the tSNE ( Figure 7 E) and UMAP model ( Figure 7 F), indicating the excellent ability of these two genes in differentiating HIV patients from healthy individuals.

tended to have higher GSRS scores" with the more precise and accurate statement: "no statistically significant difference in GSRS scores was observed between male and female patients." This immediately prevents any misinterpretation of a significant trend from the univariate analysis.

However, there is a significant trend of increase after 2019 ( Figure 5 ).

Meanwhile, the meta-analysis of this TAM-10 study and the other five reported large TAM cohorts (>40 cases) [ 3 – 6 , 11 ] identified a significant trend between a higher rate of LDAC intervention and the reduction of early death rates (Fig. 2B ).

We observed a significant trend (p trend = 0.01) between increasing WHR and EA risk in univariate analyses, but adjustment for the confounding effects of age, gender, smoking and NSAID attenuated the association substantially such that the association was no longer statistically significant (p trend = 0.16) (HR = 1.48; 95%CI 0.60–3.61, comparing extreme quartiles).

Therefore, the investigators were unable to determine whether there was a significant trend across the spectrum of gestational age.

Results: The 48-month ischemic events had a significant trend for higher event rates (from 6.61 to 16.93%) with an incremental number of risk scores presenting the higher ischemic risk from 0 to ≥3 ( p trend < 0.001).

Compared to the Q1 group, the odds ratios (OR) for the Q2 and Q4 groups were 1.45 (95% CI 1.08–1.94, P = 0.013) and 1.54 (95% CI 1.22–1.95, P < 0.001), respectively, showing a significant trend (P for trend = 0.005).

All eight of the countries with a decline in prevalence also had favourable trends in behaviours (defined as a significant trend in either men or women for at least two of the three behavioural indicators) that overlapped or started before the period of prevalence decline: Côte d'Ivoire, Ethiopia, Kenya, Malawi, Namibia, Tanzania, Zambia and Zimbabwe.

Active food packaging is a significant trend in recent years in the food industry.

Metabolic syndrome and NTproBNP The presence of metabolic syndrome increased the OR of having NTproBNP values above median levels (Table 3 , Model 3) and there was a significant trend of increasing OR through classes of metabolic abnormalities, with the lowest OR observed in people who did not have either diabetes or metabolic syndrome and the highest OR in people having both.

Discussion Numerous animal and clinical trials have shown a significant trend towards structural and functional remodeling of the brain following a stroke.

Porosity of the FFF printed coupons reduced but the authors did not find a significant trend in the strengthening of coupons.

We hypothesized that there would not be a significant trend towards IV morphine being superior to IV parecoxib for pain reduction in acute trauma pain in the ED.

Furthermore, a significant trend was observed (p trend < 0.001) (refer to Table 2 ).

The Mann–Kendall test was used to test whether the change in the included cases had a significant trend over the years.

In summary, this study investigated root growth which revealed a significant trend where lower and higher concentrations of Ranitidine appeared to inhibit growth.

Further analysis by categorizing CMI into quartiles revealed that participants in the highest quartile (Q4) had an 80% increased likelihood of PSD compared to those in the lowest quartile (Q1), with statistical significance (OR = 1.80; 95% CI 1.07, 3.02) and a significant trend ( P for trend = 0.0087).

We also observed a significant trend in coccosphere size with salinity in PLYB11 (comparable data for RCC1232 could not be reported due to insufficient data at salinity 25; Fig 4C ).

Furthermore, we observed that the levels of four lncRNAs expression had a significant trend of gradient upregulation with the addition of glycolysis inhibitor in breast cancer cells.

Currently, the shift from non‐resorbable to bioresorbable membranes, using naturally‐derived materials and/or employing principles of tissue engineering, has become a significant trend in modern GBR procedures (Bottino et al., 2012 ; Sheikh et al., 2017 ).

Of the remaining countries, three (Sweden, Canada and New Zealand) showed a significant trend for increasing prevalence, and four had significant differences detected between years without a consistent trend (Fig. 4 ).

EAC and histological IM showed a significant trend both before and after eradication ( Fig. 6 a, b ).