“a significant trend”

The null hypothesis for this analysis asserts that no trend exists in the specified quantile over time (i.e., the slope of the trend line is zero), whereas the alternative hypothesis suggests the presence of a significant trend.

A significant trend is evident in the enhancement of the sensation of incomplete defecation (reduction from 1.26 to 0.22), alongside the categories of constipation and diarrhea, which both exhibit values below 0.2 post-treatment.

According to one study, a significant trend toward increased prevalence of diabetes from 6.9% in 1997 to 11.7% in 2003 was observed in one population‐based cohort study carried out in a rural area of South Korea 8 .

When the duration of ORN employment was examined, compared with those with no history of ORN employment, those who reported 15 or more years of exposure had the greatest risk of COPD in model 3 (HR, 1.46; 95% CI, 1.10-1.93); a significant trend was observed as the years of OR employment increased, although there was only an association for 15 or more years of employment (<5 years: HR, 1.05 [95% CI, 0.90-1.21]; 5 to 14 years: HR, 1.08 [95% CI, 0.83-1.40]) ( P = .03 for trend).

Having more than three children is associated with lower OR and there exists a significant trend of decreasing risk with increasing number of children.

Thus, the integration of multi-modal data (e.g., text descriptions, amino-acid sequences, protein structures) represents a significant trend in the development of protein design models.

Preliminary exposure‐efficacy analysis in patients with CLL/SLL showed a significant trend of increased probability of best overall response with increased exposure to nemtabrutinib, while preliminary exposure‐safety in patients with hematologic malignancies showed a significant trend between increased exposure and increased probability of any‐grade drug‐related adverse events (as assessed by investigator) and any‐grade hypertension events.

We found a significant trend for decreasing resistance to NRTIs over time (6.7%–1.6%).

The P value of this test is applied to validate the credibility of the trends of [HCO 3 − ] (or WS atm-CO2 ) ( P < 0.01 presents a significant trend with low uncertainty).

If we further included in education and income variables (model 2), the significance remained for the dietary pattern score with a significant trend (p for trend = 0.0002).

A significant trend for increasing frequencies of the A allele and the AA genotype was revealed among groups ordered as hypocalcemic, normocalcemic, and hypercalcemic ( Fig. 1 ).

A significant trend in the current and future trajectory of Chinese healthcare is the increasing privatization of medical hospitals and clinics.

Likewise, a significant trend was observed in the LNCaP-LN3 cell line indicating these data are not unique to a single cell line (data not shown).

Bee richness and abundance In our study, as expected, bee species richness showed a significant trend to decrease with increasing elevation, which is in agreement with previous literature describing a pattern commonly observed in insects in general, with either a mid-elevation peak or a monotonical decrease in species diversity over the entire elevational gradient [ 34 , 35 , 37 , 38 , 50 ].

In addition, a study in Ghana did not find a significant trend between average wet bulb globe temperature (WBGT) values and odds of stillbirth or miscarriage. 46 The study suggests that every 1°C increase in heat stress exposure as indicated by WBGT resulted in an insignificant 15% increase in the odds of having a stillbirth or miscarriage in Ghana. 46 There are also mixed results on the impact of extreme heat on birth weight, with four included studies researching this outcome.

Although there was no significant difference between low and high doses of rhein in reducing LVPWd, there appeared to be a significant trend toward reduction.

The fully adjusted ORs comparing the highest tertile of DGI and DGL with the lowest tertile were 2.99 (95% CI =1.47–6.08; P test for trend = 0.003) and 4.01 (95% CI =1.2–5.91; P test for trend = 0.029), respectively, with a significant trend.

Unit 1 total normalized DOT was significantly lower than expected in waves 2 and 3; piperacillin/tazobactam level was the lowest consumption in wave 1 and showed the lowest mean across the whole 12-month period, thus preventing a significant trend from emerging.

On the other hand, if S I T A M > S s c i , the alternative hypothesis ( H o ) indicating the presence of a significant trend is applicable.

Skewness and kurtosis did not have a significant trend with the mean of distribution the gene expression as measured by the R 2 values for different polynomial fits (the R 2 values did not exceed 0.1).

The propensity score–matched time-dependent modified Cox proportional analysis HRs were 0.646 (95% CI 0.567–0.736; P < 0.001) and 0.587 (95% CI 0.512–0.672; P < 0.001) for AChEIs cDDDs of 28–365 and >365, respectively, relative to no AChEIs use (<28 cDDDs) There was a significant trend toward risk reduction with increasing doses of AChEIs (P for trend < 0.001) ( Table 4 ).

In addition, there was a significant trend in the association of incident hypertension across the categories of NDVI.

Finally, what was inconsistent with previous studies was that we had not found a significant trend in suicide mortality with latency after PCa diagnosis.

Temporal Trends in Weather Conditions and NDVI During the study period, we observed a significant trend towards higher maximum temperatures in spring–summer that can be attributed to more frequent and intense summer heatwaves (Kruuk et al. 2015 ; Lv et al. 2019 , 2023 ).

However, meta-regression results indicate that their intervention effectiveness does not show a significant trend over time.