“a significant trend”

As a significant trend, however, we observed that both resveratrol and spermidine stimulated the deacetylation of cytosolic proteins, such as ATG5 and LC3, and the acetylation of nuclear proteins, including multiple histones.

Additionally, we showed only a significant trend for the BS group.

The shift towards greener methodologies that minimize waste and reduce reliance on toxic reagents is a significant trend in contemporary organic synthesis.

In terms of passive dynamic stability, the results showed that the presence or absence of the hindwings did not show a significant trend, but the hindwings may contribute to improving flight stability depending on the direction of any perturbations.

Due to the utilization of relations between characteristics and semantics, attributes learned may become a significant trend for retrieval valid technique to its base in adversarial learning & interaction learning.

However, their detection by DyNoPy suggests a significant trend in co-evolution and highlights their crucial role in protein dynamics ( Appendix 2—figure 2 ).

Internationally, there was a significant trend towards de‐institutionalisation over the 1970s–1990s, including trialling and scaling‐up models of specialised community‐based, non‐hospital support for people with learning disabilities, such as the intermediate care programme in the USA, the Trieste model in Italy and the Andover model in the UK, as well as the development of small group homes in Nordic countries (Mansell, 2006 ).

A significant trend is the strong focus on immune checkpoint bispecific targets, particularly PD1‐CTLA4 ( n = 216 trials, 31.7%, 4 BsAbs), PD1‐VEGF ( n = 56 trials, 8.2%, 3 BsAbs), followed by oncogene targets like EGFR‐MET ( n = 34 trials, 5%, 3 BsAbs).

A significant trend across categories was also noted ( p for trend = 0.04 in Model 4). 4.3.

A significant trend of increasing diabetes risk with higher quartiles of both indices was observed.

In both men and women, significant associations were observed between the prevalence of OF and age, depressive symptoms, and current smoking habits, along with a significant trend for laughter almost every day.

Additionally there was a significant trend for early neoplasias to have a much higher fraction of cells staining positive for FOXA1 and GATA3 than normal, with positive cell fractions similar to those observed in cancer (Figure 4 B,C; Table S10 in Additional file 1 ).

Conversely, β value > 1, with the 95% CI excluding 1, reflects a wear-out failure pattern, where the risk of AEs increases over time, indicating a significant trend of rising risk with extended treatment duration.

Furthermore, a significant trend of increasing QRS area with longer QRS duration was observed ( Table 1 ).

Overall, there was a modest decline in the AAMR from 2000 to 2023, with a steep decrease from 2000 to 2009, attaining some stability till 2017, followed by a significant trend reversal and an increase in the AAMR from 2017 to 2023.

The proportion of ischemic stroke patients showed a significant trend for increment as the deciles of HbA1c increased ( P for trend <0.01).

For all compounds, there was a significant trend between dose and increasing M-PQ angle (combined plot in Figure 3 , per compound plots in Excel Figure S3).

rubella , even though there is a significant trend in the other diversity statistics ( Figure 2 ).

Advancements in on-site food optical inspections represent a significant trend in food safety and quality control.

When BP levels were divided into categories (< 120, 120–139, and ≥140 for the systolic BP and <80, 80–89, and ≥90 for the diastolic BP), there was also a significant trend toward a higher prevalence of the combined genotypes in the highest systolic and diastolic categories; 0.6% versus 3.3% versus 11.4% ( P for trend = 5.93 × 10 −5 ) and 1.1% versus 1.3% versus 14.7% ( P for trend = 3.75 × 10 −4 ), respectively [ Figure 1 ].

There is a significant trend for richer countries to have lower values.

Although this analysis is not meant to determine drivers of change, we did find a significant trend toward earlier flowering over time, when accounting for latitude.

After removal of this study, we found a significant trend across the remaining 20 studies.

Furthermore, our analysis unveiled a significant trend in the correlation between ESCC TNM staging and AS-gene frequency ( Supplementary Figures S1B, C ), as well as ASE frequency ( Supplementary Figures S1E, F ).

A significant trend involved shunt valve management, specifically converting non-adjustable (21 pre-intervention vs. 4 post-intervention) to adjustable valves (14 pre-intervention vs. 29 post-intervention), reflecting a strong shift towards adjustable systems.