“a possible trend”

We reported at endpoint (Green et al., 2015 ) a possible trend towards negative impact of the intervention on early language development and auditory neural sensitivity.

1 , 2 While modulating hyperactive mTOR pathway with everolimus may lead to a meaningful improvement in epilepsy, its effect on cognition and behavior remains less well defined. Although preclinical data suggested improvement, a 6-month long administration of everolimus to children with TSC in a randomized, placebo-controlled trial showed a possible trend but not a statistically significant improvement in neurocognitive functioning or in behavior, and similar results were noted in EXIST-3 substudy in Japan. 5 , 7 Considering the logistical challenges of these trials (patient heterogeneity, confounding effects of medications, comorbid conditions, and others), results of these clinical studies hardly mean absolute lack of efficacy but rather highlight the biological complexity that underlies neurocognitive dysfunction in TSC.

( 2004 ) observed a possible trend for certain unfavorable prognostic parameters (e.g., young women, low-graded tumors, human epidermal growth factor receptor 2 over-expression) that could be related to higher serum levels of sE-selectin.

There is a possible trend of an improvement of mean change of BCVA from 1 to 12 months after surgery, except at 6 months (Figure 2 ).

There is a possible trend for Treeline homozygotes or Treeline/Arrowhead heterozygotes to be more polyandrous, but the rates of polyandry are within the range shown by other karyotypes, and the sample size is too small for useful statistical analysis.

This is concerning for systems development, cost containment and quality of care, as it demonstrates a possible trend shifting away from primary care as initial access point.

The available evidence suggests a possible trend toward a higher frequency of leiomyomas among patients with CCCA.

Table 2 shows that the ratio between M1 and M3 length is higher in Batallones 3 than in Batallones 5 implying a possible trend towards relatively smaller M3, not observed on theoretically more advanced forms of Rotundomys .

There is a possible trend for E. coli with highest values in September and lowest in December and an opposite pattern for ACC, but these are not statistically significant (Table 2 ).

A borderline moderate positive correlation was found between LD-BMA therapy duration and OHIP-14 impact scores ( ρ = 0.29), suggesting a possible trend toward reduced perceived oral quality of life with longer treatment. 4 Discussion The present study aims to assess dental and periodontal health status and quality of life in patients under LD-BMA therapy for CTIBL.

To discern a possible trend reversal, a comparison must be made between teaching before and after the COVID-19 outbreak.

Patients receiving lower fluid volumes (<0.15 mL/kg/min) had lower overall complication (19% vs 25%) and leak rates (3.2% vs 6.2%); however, these differences did not reach statistical significance, indicating a possible trend toward benefit [ 33 ].

While the observed differences are consistent with previous reports, the current findings should be viewed as indicative of a possible trend, rather than conclusive results.

The Cochran–Armitage trend test was used to evaluate a possible trend of the risk of pancreatic cancer across decreasing levels of dental health status (inflammation), and the number of teeth.

Still, source attribution in human cases is far from complete [ 60 ], which means that the role of RMBDs in human infections, or a possible trend towards increased human cases due to the handling of RMBDs cannot be assessed properly.

Our finding of a possible trend toward elevated gene expression of CD11b after 12 hours in the HT group compared with control is not easy to interpret.

Conclusions This pilot study suggests a possible trend toward more favorable immune recovery patterns following postoperative administration of a multivitamin and mineral complex containing A. blazei in patients with NSCLC, warranting further validation in larger long-term studies.

It is important to note however, the results of the modulation assays simply indicate a possible trend towards efflux inhibition rather than a precise prediction [ 41 , 42 ].

While GCN2 depletion did not have a detectable impact on LC3B or p62 levels in most conditions tested, we observed a possible trend to higher LC3BII levels in shGCN2 compared to shNTC cells that were glutamine-depleted, irrespective of whether they were or were not treated with CB5083.

In peripheral blood of unaffected carriers of 17 heterozygous PRKN variants and controls, identified previously in the population-based CHRIS study 11 , a group comparison suggested a possible trend towards increased mtDNA copy number in heterozygous PRKN variant carriers.

Although the confidence interval for this value indicates a great variability in the data, this could indicate a possible trend [ 48 ].

Dapagliflozin, on the other hand, suggested a possible trend toward lowering the incidence of respiratory system malignancies, while statistical significance remained elusive.

As we planned to conduct an exploratory analysis to find a possible trend of gender effects in smiling interaction, a total of 40 participants (20 females, mean and standard deviation [SD] of age: 25.7 [±3.0] years) were recruited as speakers.

Scatter plots of RNFLT with SARA score and disease duration are given in figures 3B and 3C , respectively, proposing a possible trend for a correlation of RNFLT with SARA score.

The findings indicated no significant difference between the two interventions in improving depressive symptoms, response rates, or general psychiatric symptoms, with a possible trend toward fewer adverse events in the HM group.