When compared to standard-dose therapy, direct MT without thrombolysis demonstrated a nonsignificant trend toward decreased risk (aOR 0.62, 95% CI: 0.25–1.49; P = .289).
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19 The association between TMB and treatment response was evaluated in two studies with 121 patients, with a nonsignificant trend suggesting potential benefit in high TMB status (OR, 2.17; 95% CI, 0.51–9.17; P = 0.29; I 2 = 56%) (Figure 4B ).
A linear regression model predicting category goodness scores revealed a nonsignificant trend for females of average age (the reference level) to score lower online than in person ( β = -2.38, SE = 2.24, p = 0.29).
The percentage of potential T-cell responses achieved in each category revealed a nonsignificant trend toward higher responses among ACPA + RA patients to the created peptides (33%) than to no change (17%; P = 0.2918) and destroyed (13%; P = 0.1692) peptide groups, in addition to significantly more frequent responses among ACPA + RA patients to the created peptides (33%) than observed for the controls by χ 2 test (2.5%; P = 0.0002; Fig. 6b ).
There was a nonsignificant trend for a lower grade 3+ toxicity rate in the intervention cohort (43.8% vs 52.9%, P =0.292; Table 5 ).
There was a nonsignificant trend toward higher corticosteroid doses (7.8 ± 8.5 versus 5.0 ± 1.7 mg/d; P = 0.3) and a higher proportion of tacrolimus-treated patients at ICI initiation (46% versus 22%: P = 0.3) in the nonrejection group.
In addition, deletion of the selw gene resulted in a nonsignificant trend toward reduced lesion formation ( P = 0.3) ( Fig. 4C ).
4 b), with a nonsignificant trend toward more time until surgery (MD = +3.12 days, 95% CI: −2.81–9.04, p = 0.3).
There was a nonsignificant trend toward a higher 30-day readmission rate in the inpatient group than in the outpatient group (3.2% v. 0.0%, p = 0.3).
In the univariate model, Karnofsky performance status > 80% was associated with a significantly better PFS (HR 0.37, 95% CI 0.19–0.76, p = 0.003), and CCI ≤ 2 showed a nonsignificant trend toward improved outcomes (HR 0.73, 95% CI 0.40–1.34, p = 0.3).
Evaluation of smoking status found a nonsignificant trend toward earlier time to VTE formation among former and active smokers compared with never-smokers by log-rank analysis ( P = .30).
Similarly, serum albumin levels showed a nonsignificant trend toward higher values in the sarcopenic group (3.97 ± 0.77 g/dL vs. 3.74 ± 0.81 g/dL; p = 0.302).
OS did not significantly differ between patients treated with PCI-27483- GEM and those with GEM alone but there was a nonsignificant trend toward longer PFS in patients receiving PCI-27483- GEM compared to those receiving GEM alone (PFS: 3.7 months vs. 1.9 months; HR 0.62; p = 0.307) [ 99 ].
Cardiovascular Cardiac symptoms suggestive of heart failure were reported in 9.2% (n = 6), with a nonsignificant trend toward higher frequency in idiopathic patients (16.7% vs 7.5%; P = .31).
Histology and immunohistochemistry showed increased average staining for CD68+ macrophages in SuHx livers (1.60% vs 0.93%, p = 0.003) with a nonsignificant trend toward increased fatty deposition (12.22% vs 4.86%, p = 0.31).
There was also a nonsignificant trend in the HIS stratum (OR = 1.75 [0.61–4.98]; p = 0.31), but the variant was much rarer (freq = 0.015) and not imputed as well (Rsq = 0.577).
Respiratory complications showed a nonsignificant trend favoring SSA but with substantial heterogeneity (RR = 0.41, 95% CI 0.07–2.29; p = 0.31; I2=65%) (Figure S15).
However, a nonsignificant trend toward higher 30-day mortality can be seen in the hemodynamic instability group (22.7% vs. 13.9%; p = 0.3108).
This interaction reflected the finding that right-hand responses were more accurate when pressing the lower key than when pressing the upper key, t (79) = −2.992, p = .004, d = −0.335 (two-tailed test, while a nonsignificant trend in the opposite direction occurred for left-hand responses, t (79) = 1.019, p = .311, d = −0.114 (two-tailed test).
While short-term therapy (<3 years) showed a nonsignificant trend toward improved survival compared with no treatment (P = 0.311), only treatment durations exceeding 3 years resulted in a significantly superior survival outcome (P = 0.004).
A nonsignificant trend (p=0.3125 and p=0.1953) of increase in ORP levels compared to the control was observed in all study groups after 240 and 300 minutes of incubation, respectively.
Moreover, a poor ECOG performance status showed a nonsignificant trend for predicting shorter PFS (ECOG PS 0 versus ECOG PS ≥ 1, 4 months versus 7 months, HR = 0.585 (0.358–0.956, p = 0.32).
There was a nonsignificant trend toward a decrease in the median sodium fractional excretion after dDAVP injection in patients affected by central diabetes insipidus, from 1.22% to 0.44% ( P = 0.32) and remained stable in patients affected by nephrogenic diabetes insipidus (1.42% to 1.39%, P = 0.32, Fig. 1 ).
We noted a nonsignificant trend toward less increase in LV mass in the vitamin D arm ( P =0.32).
Interestingly, when comparing GPNMB levels across different disease stages within the same cognitive status groups, we observed a nonsignificant trend toward higher levels in patients with advanced-stage PD than in patients with early-stage PD (PD-NC: 24.21 ± 0.82 vs. 25.77 ± 1.48, p = 0.32; PD-CI: 30.22 ± 0.93 vs. 31.16 ± 1.42, p = 0.56).