“a nonsignificant trend”

We also tested whether the decrease in IL-1β release upon CLIC1 blockade may involve actin-binding ERM proteins, since actin-dependent processes can modulate NLRP3 function ( 52 ), but we only observed a nonsignificant trend toward lower IL-1β levels upon blockade of ERM proteins with NSC (fig.

In gastrocnemius muscle of KO mice, there was also reduced accumulation of CD206 + macrophages and a nonsignificant trend for reduced CD86 + macrophages ( Figure 2F ).

On multivariable Cox proportional hazards regression analysis, lymphovascular space invasion was the only significant prognostic factor for RFS, whereas pathological upstaging showed a nonsignificant trend ( Table 3 ).

9 More recently, a UT—MD Anderson trial comparing SRS to WBRT in patients with 4 to 15 metastases demonstrated improved neurocognitive function, numerically improved OS, comparable local control, and a nonsignificant trend toward inferior overall intracranial control, though it is important to note that this trial was terminated early and has only been published in abstract form. 10 Therefore, prospective evidence supports treatment of up to 15 lesions with SRS, although many centers consistently treat larger numbers of lesions with apparent safety.

However, this review also noted a nonsignificant trend toward increased anxiety seen in patients who were given a choice over music type ( Hole et al., 2015 ).

Among these patients, achieving SGRQ responder status at 6 months was negatively associated with an increased frequency of acute exacerbations (odds ratio, 0.246; 95% confidence interval, 0.050 to 1.207; p=0.084), showing a nonsignificant trend.

Available tolerability data indicated only a nonsignificant trend for more diosmectite than placebo recipients to experience constipation.

Subgroup analysis excluding participants with awareness of gallstones still showed a nonsignificant trend for this symptom complex and incident gallstones.

41 , 42 , 43 , 44 , 45 Furthermore, Berry et al 25 reported no statistically significant difference in mortality between pregnant and nonpregnant women with TBI after adjusting for confounding variables, although a nonsignificant trend toward increased mortality in pregnant patients with TBI was noted.

There was a nonsignificant trend for higher risk of death in the low-adherence group (adjusted HR = 1.14, 95% CI = 0.88, 1.47).

19 Lechiancole and colleagues 20 demonstrated similar findings in older patient cohorts, showing a nonsignificant trend toward improved survival associated with mech-Bentall over bio-Bentall for patients older than age 65 years with aneurysmal disease.

23 In pigs, 700 μg/kg solCD39 increased bleeding times but achieved only a nonsignificant trend to attenuate platelet and fibrin deposition after coronary balloon injury. 21 In our study, we combined soluble forms of CD39 and GPVI‐Fc to form a recombinant, bifunctional protein, GPVI‐CD39, to investigate platelet‐mediated thrombus formation.

S4E ), but only a nonsignificant trend for decrease in its protein levels ( Supplementary Fig.

Finally, when analyzing REM sleep, we again detected a decrease in the delta power density and an increase in the theta power density in Ts Veh compared with WT Veh at baseline ( Figure 1 D, middle ), with an increase in theta power but a nonsignificant trend toward delta power at recovery ( Figure 1 D, right ).

Similarly, we observed a nonsignificant trend in isolation by environment, with an R 2 value of 0.001 and p value of 0.83 (Figure S9C ), indicating that genetic structure is not well explained by environmental distance.

A nonsignificant trend was seen for patients with high plasma lignan levels.

Protein and fat intake were similar in the 2 groups, whereas there was a nonsignificant trend for lower total carbohydrate intake in the clinical improvement group ( Supplemental Table 1 ).

Regarding age, we observed a nonsignificant trend toward younger patients presenting with mature cataracts after the pandemic, a pattern also seen in Indian and Asian populations [ 5 , 15 ].

Hyperglycemia developed in the corticosterone– Agrp +/+ mice after 3 weeks, and a nonsignificant trend was found toward an increase in blood glucose levels in the Agrp −/− mice ( Fig. 7e ).

While external validation in the GSE140275 bulk RNA-seq dataset showed only a nonsignificant trend toward decreased F2 expression in stroke patients, this could be attributed to factors such as the limited sample size, tissue heterogeneity, or the specific timing of sample collection poststroke.

In CD, primary BAs are increased in patients with prior ileocolonic resection, while a nonsignificant trend towards lower secondary BAs is observed in surgery samples.

Hypertension showed only a nonsignificant trend toward increased risk after multivariable adjustment.

A nonsignificant trend toward more relapses was seen in tailored group at 28 months (OR: 1.91, [95% CI: 0.75, 4.83], very low certainty of evidence).

During the DOWN phase (450 to 480 sec), there was a nonsignificant trend toward recovery, compared to the UP position (Fig. 3 , DH 48.75 ± 12.64 to 50.11 ± 13.67 cm·sec −1 ; NDH 49.31 ± 12.91 to 52.36 ± 14.61 cm·sec −1 ).

In this study, we found a nonsignificant trend between various baseline immune cell densities and T-DXd efficacy and detected a significant difference between baseline CD20 + cell densities in responders and nonresponders.