“a nonsignificant trend”

Neither CRP ( Figure 4A ) nor TNF-alpha ( Figure 4B ) serum levels at completion of treatment changed significantly from baseline in either participants in the yoga therapy or the standard of care groups, although there was a nonsignificant trend toward improvement in the yoga therapy arm.

The researchers concluded the Mg and vitamin E cosupplementation over 12 wk among women with PCOS improved markers of cardiometabolic risk with a nonsignificant trend towards improved insulin sensitivity ( 41 ).

In the subgroup without CKD at baseline, a nonsignificant trend was observed for the prespecified end-point of a 30% reduction in eGFR (measured twice ≥90 days apart) to an eGFR < 60 ml/min per 1.73 m 2 , initiation of dialysis, or kidney transplantation (HR = 1.64, 95% CI = 0.85−2.93, P = 0.114 recessive model), but not for incident proteinuria.

Effect of PET scanning on appropriate decision showed a nonsignificant trend towards a reduction in the predefined composite endpoint (cardiac death, myocardial infarction, or cardiac rehospitalization) at one year (Hazard Ratio 0.78, 95% CI 0.58 to 1.1; p = 0.15), with post hoc analysis showing a statistically significant reduction in adverse events in the FDG PET-assisted group (Hazard Ratio 0.62, 95% CI 0.42 to 0.93; p = 0.019) [ 58 ].

Using a ceremide-based emollient, the Prevention of Eczema By a Barrier Lipid Equilibrium Strategy (PEBBLES) study showed a nonsignificant trend toward reduced AD and food sensitization at 6 and 12 months [ 80 ].

A nonsignificant trend for partial smoking to improve IED performance was also observed in the analysis of total number of errors prior to the extradimensional shift block (main effect of smoking condition on Blocks 1–7; F [1,42] = 2.98, p = 0.053).

concluded that more clinically complex patients have a nonsignificant trend toward a higher rate of single positive findings. 3 Karaca et al. found that many cases of presumed phenotypic expansion are actually patients with multiple Mendelian conditions. 2 Posey et al. used Human Phenotype Ontology (HPO) terms to determine the degree of phenotypic overlap of individual patients’ dual diagnoses. 4 To our knowledge, however, this study is the first to compare clinical complexity between patients with single and multiple potentially relevant findings.

Consequently, only a nonsignificant trend towards higher CD8 + T-cell levels was seen in αCD40-treated Xcr1 wt/dtr mice, which was incapable of restricting B16F10 tumor growth ( Fig. 3F ).

[ 29 ] who observed a nonsignificant trend towards improved global cognition in consistent equol producers.

Similarly, preliminary results of a recent randomised trial of preoperative chemotherapy (paclitaxel and carboplatin) have shown a nonsignificant trend towards improved progression-free survival and overall survival (OS) ( Pisters et al , 2005 ).

Therefore, although previous studies have suggested a nonsignificant trend toward a protective effect of mouthguards in collision sports, rigorous case-control designs are required to further evaluate this finding.

There was a nonsignificant trend for cases with suture tension irregularity having a higher rate (3-fold) of granuloma compared with those with regular suture tension in both PLTR (5.0% vs. 13.3%) and BLTR (2.1% vs. 6.7%) procedures.

However, in one study that included nondiabetic patients with known cardiovascular disease, pioglitazone resulted in a nonsignificant trend toward increased ESR [ 41 ].

The mean age difference ( Figure 2 ) between the surgery and embolization group was 3.60 years (95% confidence interval [CI]: −0.90, 8.10; P =0.12; I 2 =73% [random effects model]), with a nonsignificant trend towards older age in the embolization group.

We found that H3K4me3 levels were significantly increased in all regions in TM hypothalamus samples from biological replicates thus confirming ChIP-seq data except for CCNF that only showed a nonsignificant trend toward an increase ( Figure 1D and data not shown).

The median TTR was 5.6 months per protocol and 4.6 months when analyzed clinically 1 ; there was a nonsignificant trend toward shorter TTR when analyzed according to iwCLL clinical recommendations ( Figure 1 A).

Lysosomal enzyme activities appeared normal across all SPG15 and SPG11 cell lines tested, though there was a nonsignificant trend toward slightly decreased activity (Fig. 7 ).

There were significant increases in the cytochrome P450–derived vasodilator EETs and DHETs (8,9-, 11,12-, and 14,15-DHET) and a nonsignificant trend for an increase in the lipoxygenase-derived 12- and 15-HETE vasodilators ( Fig. 2 C and D ).

20 This led to a phase II randomized trial with guadecitabine plus carboplatin compared to physician choice that showed a nonsignificant trend for improvement in overall PFS (16.3 weeks vs. 9.1 weeks). 21 However, the 6‐month PFS was significantly higher in the guadecitabine plus carboplatin group (37% vs. 11%, p = 0.003), validating the potential utility of HMAs as re‐sensitization agents. 21 A phase I study also demonstrated early promising results for the use of guadecitabine plus irinotecan in metastatic colon cancer. 42 The MTD of our trial was determined to be 30 mg/m 2 guadecitabine day 1 through day 5 and 100 mg/m 2 cisplatin on day 8 of a 28‐day cycle.

There was a nonsignificant trend toward increased baseline spine elimination rate in MECP2 -duplication mice versus littermate controls across the 8 d of imaging ( Fig. 1 I , J ), although our study was not statistically powered to detect this difference given variability in WT animals (1−β = 0.60 for d1→5; 1−β = 0.64 for d5→9).

Examination of miR-21 and miR-155 expression in melanomas with differing growth phases revealed a nonsignificant trend towards increased miR-155 and miR-21 expression in melanomas exhibiting an incipient or fully evolved vertical growth phase as compared with melanomas with only a radial growth phase (data not shown).

There was a nonsignificant trend for shorter median first-line cPFS in those with TP53 mutations (9.4 months, 95% CI: 8.9–not reached) compared with those without (92.4 months, 95% CI: 15.8–not reached, P = 0.09; Fig. 2D ).

There was a nonsignificant trend for small lesion size to be inversely associated with rates of study hemorrhagic outcome events within 90 days (Figure 8 ).

In addition, there was a nonsignificant trend for greater reductions in ΔSBP, ΔDBP, and ΔMAP in patients on recommended drug class for beta-blockers, diuretics, and angiotensin II receptor blockers vs patients not on these classes.

An Ethiopian study found a nonsignificant trend for “skin ulcers” to be protective against mortality ( 27 ).