“a nonsignificant trend”

In this subset, a benefit in PFS was observed as well as a nonsignificant trend toward benefit in overall survival, reinforcing tivozanib as a viable option in this setting.

Moreover, there was a nonsignificant trend toward increased all-cause mortality in the pravastatin group vs. the placebo group.

Increasing dietary MEL in low-Trp diet showed an increasing trend on quail growth and the interactive effect of Trp × MEL revealed a nonsignificant trend on G 7–28 ( Figure 3 A).

After treatment, grip strength differed between SCI group and FMT group showing a nonsignificant trend of improvement at 7 day post-injury (dpi), 14 dpi, and 21 dpi.

117 However, the subsequent 3-month study of Rennard et al found only a nonsignificant trend toward better quality of life in the salmeterol arm compared to placebo. 118 The early studies found no difference in mortality between LABA and placebo, arguably because of their short durations.

NOAC showed a nonsignificant trend for a lower risk of ICH when compared to warfarin (HR: 0.843, 95% CI: 0.523–1.321, Figure 3 , panel A).

Ruxolitinib was associated with a nonsignificant trend towards improved PV ‐related symptoms versus hydroxycarbamide, although an unexpectedly large proportion of patients who maintained their hydroxycarbamide dose reported symptom improvement. polycythaemia vera quality of life signs and symptoms Janus kinase hydroxycarbamide Incyte Corporation Treatment dose modifications were permitted for safety and efficacy and to optimize response for each patient.

23 However, the authors also observed a nonsignificant trend for patients with low TPMT activity to have higher incidence and shorter onset of secondary acute myeloid leukemia as well as higher cumulative incidence of brain tumors when compared with patients with wild-type. 52 , 53 In their later trial, Total Therapy Study XIIIB, which included 247 patients

In this study, a nonsignificant trend toward greater increases in ELF score were observed in higher risk patients.

At D21 post-ChAdOx1 NP+M1 vaccination, there was a nonsignificant trend toward higher responses in vaccinees who received the highest dose (5 × 10 10 vp) of ChAdOx1 NP+M1 (1,197 SFUs/10 6 PBMCs), when compared with the lowest dose group (5 × 10 8 vp; 298.3 SFUs/10 6 PBMCs).

There was a nonsignificant trend to increased bleeding in the quintile with the greatest platelet response. 39 In a randomized trial comparing proceeding to PCI after 600 mg clopidogrel load vs one or more reloads if platelet response was subtherapeutic as measured by the VASP index, Bonello et al demonstrated a lower clinical event rate with platelet function assay guided clopidogrel therapy. 40 The GRAVITAS trial failed to show a clinically significant benefit to increasing the maintenance dose of clopidogrel to 150 mg daily in low responders to the loading dose as measured by the VerifyNow ® assay.

Moreover, we observed a nonsignificant trend toward an increase in LPS-related functional pathways (LPS biosynthesis and LPS biosynthesis proteins) in HT participants compared to HC and non-HT subjects ( Figure 5 D and E ).

There was a nonsignificant trend toward lower in-hospital mortality after the transition (2.24% vs 0.83%).

Conversely, we observed a nonsignificant trend suggesting a potential protective effect of higher fruit intake, consistent with findings that fruit consumption is associated with reduced behavioral symptoms [ 14 ] and that traditional, nutrient-rich diets may mitigate symptom severity.

We observed a nonsignificant trend showing that the risk of stroke was increased by 48% in patients with HAPR compared with patients with NAPR.

In contrast to lever pressing, significant decreases in the number of nose pokes to the reward delivery port were observed in the devalued condition for all groups, except for the first test of the VI + VI group, which exhibited a nonsignificant trend toward reduction.

The Seattle–King County study reported a nonsignificant trend toward higher INH-related hepatotoxicity in women compared with men, although the incidence of severe hepatotoxicity was relatively low in both men and women. 23 The USPHS study showed no overall difference between women and men in rates of probable INH hepatotoxicity. 7 The San Diego and Memphis s

Patients with hematological malignancies showed a nonsignificant trend for earlier occurrence of severe events compared to solid tumor patients (severe event free survival for hematological cohort = 30% vs severe event free survival for solid cohort = 61.4%, Figure 1E ), had a longer duration of hospitalization (median hematological = 21 days vs median solid cohort = 13 days), and required a longer time to achieve a clinical improvement (median hematological cohort = 18.5 days vs median solid cohort = 11.5 days). 3.7.

Between the different radioactive treatment groups, there was a nonsignificant trend towards more pronounced tumor growth suppression at higher dose of 224 Ra and by repeated treatment.

On HbA1c, there was a nonsignificant trend toward deteriorating HbA1c after brief intervention.

S2A), with a nonsignificant trend toward improved tumor control with xevinapant and RT alone (Supplementary Fig.

RAB11FIP5 −/− mice exhibited only a nonsignificant trend for higher average tier 1 (neutralization-sensitive) virus neutralization titers ( Fig. 6C ).

Furthermore, the average plasma levels of bilirubin (total and conjugated bilirubin) were significantly increased by three- to sixfold in CDAHFD-fed minipigs after 2, 4, and 5 mo on CDAHFD ( Table 1 ), and a nonsignificant trend toward decreased plasma levels of iron were also observed in minipigs on CDAHFD ( Table 1 ).

There was a nonsignificant trend toward higher calculated LVAD flow in the macitentan group.

Our main findings were as follows: (I) there was no significant difference in LGE% of myocardium between sexes; (II) males had a higher risk of non-infarct-related LGE, whereas infarct-related LGE showed only a nonsignificant trend; (III) extracellular volume did not differ significantly between sexes; and (IV) there was no significant difference in septal E/e′ between sexes.