Excerpts

ActiveDriver identifies N-terminal mutations in five cancer types as highly significant ( n = 73, FDR p = 2.5e − 92 from ActiveDriver; Fig. 2b ), confirming constitutive activation of CTNNB1 via disrupted phosphorylation as a prevalent driving mechanism of cancer.

Importantly, 64 of the 126 genes were also repressed when Miz1 and Arf were coexpressed, identifying a highly significant overlap in target genes (P = 2.5 × 10 −92 ) and defining a core program of genes that are jointly repressed by Myc and Miz1 in the presence of Arf ( Fig. 6 b ).

We also showed confirmed association with AGA at AR gene by highly significant signal spanning the gene region (OR = 2.20, 95% CI = 2.04–2.37, p = 2.40×10 −91 for risk allele T of top SNP rs2497938).

Homologous motif prediction using the MEME Suite (v5.5.9) identified four highly significant conserved motifs ( p < 1 × 10 −90 ) in human WEE2 and its family kinases.

On the other hand, there were 180 genes differentially regulated by both dfoxo and Xbp1 s overexpression in the fat body ( Figure 4 C) and this overlap was highly significant ( p < 10 −90 ).

6 E ), a highly significant overlap ( P = 1.03 × 10 −90 ).

These effects were also highly significant if APOE was not included in the NN calculation of CV [CV vs. age, F (2,4752) = 422, β = −22.4, p = 5.3e-90; CV vs.

The most top and highly significant miRNA involved in this pathway was hsa-miR-34a-5p ( p = 1.275767 e − 88) with 28 target genes, including MET oncogene and three angiogenesis-related genes ( VEGFA , TGFB1 , TGFB3 ).

For the chloroplast genome, the average sequencing depth (the average number of reads representing a given nucleotide; also referred to as read depth or average cover) of silica gel dried material was 1.7 times higher than that of herbarium material, and this difference was highly significant (Mann-Whitney p = 1.8 × 10 −88 ).

These overlaps are very unlikely to occur by random chance, as even the protein pair with least common probesets has a highly significant P -value ( MCM5 and MCM6 , 47 common probesets, P < 10 -87 ).

The association of CDS Htz1 peaks with AS transcripts, although lower than the association of 3' Htz1 peaks with AS transcripts (Figure 3 D), is highly significant ( p = 1.6 x 10-87; Fisher’s exact test).

Comparing synchronized neurons with a fixed I-E delay of 5 ms, we observed a highly significant correlation (r = 0.99, P<3.1x10 -87 , Spearman Correlation, Fig. 4b ) between the excitatory input strength and the Rayleigh statistic, the criterion we used to measure the statistical significance of stimulus-synchronization.

First, we considered the intersection between differentially expressed genes and genes that are neighbours of misregulated TEs at the 2-cell stage, and discovered a highly significant overlap of 12% between the two populations (p=3.19 × 10 −87 ) ( Figure 4A ).

A Mann–Whitney U test confirmed the difference was highly significant ( U = 130,876, p < 1e-86, Cohen’s d = 2.05), indicating a large effect size.

The three participant-specific tests revealed highly significant deviations from the uniform distribution (PA: χ2(7, N = 189) = 421.50, p = 10 -86 ; PB: χ2(7, N = 94) = 107.36, p = 10 -19 ; PC: χ2(7, N = 126) = 512.73, p = 10 -105 ).

This demonstrated that BAF and p63-dependent target genes (fold change > 3 with depletion, FDR < 0.01) displayed highly significant overlap ( p = 2.1 × 10 −86 ), with 236 genes controlled jointly by both BAF and p63 (Fig. 2h ; Additional file 1 : Figure S2f, g; Additional file 2 : Table S2).

LD score regression analysis revealed a genetic correlation coefficient of rg = 0.23 (95% confidence interval [CI]: 0.203 to 0.249; se = 1.15 × 10 − 02 ), which was highly significant ( P = 2.65 × 10 − 85 ).

For viscosity–transparency relationships, ANOVA demonstrated a highly significant association (F = 244.94, p < 1 × 10 −84 , R 2 = 0.98), where viscosity nearly fully explained transparency differences—likely linked to enhanced molecular alignment or suppressed phase separation in high-viscosity systems—with a negligible C.V.

This was found to be highly significant (p<10 -84 , hypergeometric distribution).

In single-variant analysis adjusted for age, sex, and the shorter apo(a) isoform, we determined that both PNR alleles were associated with a highly significant Lp(a) decrease (PNR10: β = −14.43 mg/dl, 95% CI: −15.84, −13.02, P = 3.33e-84; PNR11: β = −17.21 mg/dl, 95% CI: −20.19, −14.23, P = 4.01e-29).

Among a set of 477 genes showing estrogen-induced expression in MCF7 cells ( Figure 6D , “E2 induced”), 115 showed loss of expression in response to ELF5-V5, an overlap with a highly significant p -value ( p = 5E−84) and odds ratio (OR = 16).

In aggregate, down-regulation of predicted ceRNA targets was highly significant ( p ≤ 6.0E - 84 for each time point and cell line).

GDF11 and the EGF receptor inhibitor AG1478 regulated a common set of 2466 probes, with a highly significant ( p <10 −83 ) r value of 0.37.

For instance, the enrichment of EGR1 binding sites on hypomethylated regions in excitatory-neuronal subtype mL4 is highly significant (odds ratio: 1.7, Binomial test, p -value = 6.7e-83).

Genome size remained a highly significant predictor of the number of metabolites in the microbial genomes per species ( β = 6.99 × 10 −5 , p = 6.97 × 10 −83 ), indicating that genome completeness does not confound the observed relationship.