Barely Significant

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highly significantp < 0.00010.0× alphaqualifiedgold
There is no consensus on how p-values should be estimated for linear mixed models, but following the t-statistics obtained from using the Satterthwaite’s method, the effect of the participant’s role (whether proposer or recipient) was highly significant (p < 0.0001) whereas the effect of the depression diagnosis and the role:depression interaction were not.
highly significantp < 0.00010.0× alphaqualifiedgold
This ANOVA yielded a highly significant main effect of Language [F(2,696) = 16.872, p < 0.0001, η 2 = 0.046], mainly driven by the significant differences between English and French (p < 0.001), and English and Spanish (p < 0.0001), with the difference between French and Spanish being non-significant (p = 0.063), as shown by LSD post hoc tests.
highly significantp < 0.00010.0× alphaqualifiedgold
The one-way ANOVA results confirmed highly significant differences ( p < 0.0001) across the median normalized log2 signal intensities in all five examined subcellular fractions, with the strongest effects observed in the endoplasmic reticulum ( p = 5.6 × 10−14, F = 1134) and mitochondria ( p = 1.8 × 10−12, F = 599), where the addition of DDM substantially increased signal intensity.
nominally significantp < 0.00010.0× alphagold
Given this lack of statistical significance in hierarchical testing, adjusted mean changes from baseline in total lesion volume on T2-weighted (T2W) images at 12 months and 24 months in the siponimod group were considered nominally significant versus placebo (both timepoints p < 0.0001) (Table 1 ), with the adjusted average mean increase from baseline over both timepoints lower in the siponimod than placebo group (183.9 vs 879.2 mm 3 ; nominal p < 0.0001) [ 38 ].
highly significantP < 0.00010.0× alphaqualifiedgold
Together with the highly significant differences (Two‐tailed paired t ‐test P < 0.0001; n = 65) in the average (±SD) counts of unique gene clusters obtained from complete versus complete plus partial gene catalogues ( Supplementary Data 1 ) suggests a strong effect of partial gene sequences on gene diversity, and in turn, gene discovery.