Excerpts

In comparison to ∆ odc mutants supplemented with polyamines, the difference was highly significant, with p < 0.0001 observed on days 4, 7, and 10.

For the IGRA, comparisons between ChAdOx/ChAdOx and both heterologous regimens also revealed highly significant differences ( p < 0.0001) with stronger results for the heterologous regimens, but no statistically significant difference between both heterologous regimens ( p = 0.812; see Figure 5 ).

At 0.50× and 0.75× MIC the effects were uniformly highly significant for all isolates and both combinations (mostly p < 0.0001).

At 72 h, a highly significant reduction in cell viability ( p ≤ 0.0001) for both RIPs was already evident at 10 −9 M.

In contrast, particularly at 10 μM, a highly significant ( p < 0.0001) anti-clonogenic effect (26% inhibition) was found in MDA-MB-468 cells after three hours of exposure; meanwhile, there was a gradual decrease with increasing TQ concentration, exhibiting a significant 90% inhibition of colony formation at the highest tested concentration, 50 μM.

The difference was highly significant (unpaired t -test, p < 0.0001).

These correlations were, however, quite significant at occipital electrodes: (meditation—O1, r = 0.77, P = 0.0001, O2, r = 0.71, P = 0.002; control—O1, r = 0.79, P = 0.0001, O2, r = 0.75, P = 0.001.

During the C1INH-nf treatment periods, subjects showed a highly significant (p < 0.0001) decrease in HAE attacks (6.26 versus 12.73 attacks; p < 0.0001).

The quadratic effects of A 2 , B 2 , and C 2 on AChE inhibitory activity were highly significant ( p < 0.0001, Figure 2 M–O).

A highly significant difference was found between the parental lines in MI ( P ≤ 0.0001), with 53.9 ± 1.97 and 70.7 ± 1.97 for IGC119 and Harari, respectively (Fig. 1 b).

For all parameters in the Friedrichs criteria in both active and placebo group, the p -value from screening to weeks 1, 2 and 4 was highly significant ( p value ≤ 0001).

The correlations between both phases were highly significant (Student’s t -test), as can be observed for V1/V2 ( Figure 8 D; r = 0.965, p < 10 −4 ), d1/d2 ( Figure 8 E; r = 0.898, p < 10 −4 ), V1/d1 ( Figure 8 F; r = 0.675, p = 0.002), and V2/d2 ( Figure 8 G; r = 0.753, p = 0.0003).

22 These data demonstrate a highly significant bias for NS3 P319L in mosquitoes (chi-squared, p < 0.0001).

In all cases, differences were highly significant ( p < 1 × 10 −4 ): A . bandense , p = 4.76 × 10 −7 ; D . pealeii , p = 2.38 × 10 −5 ; E . berryi , p = 1.37 × 10 −5 ; I . argentinus , p = 2.13 × 10 −6 ; I . illecebrosus , p = 2.77 × 10 −5 ; O . bimaculoides , p = 2.06 × 10 −8 ; S . officinalis , p = 1.06 × 10 −6 ; and A . bandense juvenile skin swabs, p = 4.77 × 10 −49 .

Analysis revealed a highly significant main effect of Time, F (2.79, 78.21) = 35.34, p < 0.0001, η 2 p = 0.56, 95% CI [0.50, 0.60], demonstrating that repeated stimulation produced consistent modifications in reflex amplitude throughout the protocol.

The content of each individual element, except Fe, showed highly significant differences between the inner structure and the surface (results from Wilcoxon‐test: p < .0001*, for p ‐values see Table A1 ).

The amount of MON deposition under infinite-dose conditions was examined from three formulations: MON-NLC, MON-NLC gel, and MON in water across the epidermis, dermis, and the receiver chamber of the Franz diffusion cell after 24 h application ( Figure 11 ). A significant finding was that the MON-loaded NLC gel left much less MON on the skin surface (59.50 ± 505.81 ng/cm2) as extracted from the skin wash compared to the MON-loaded NLC (14313.11 ± 118.88 ng/cm2), with a highly significant p-value of <0.0001.

The p -value was highly significant ( p < 0.0001) and the lack-of-fit p -values were larger than 0.05 (0.1673, 0.6943, and 0.7078, respectively).

A univariate logistic regression model for predicting the diagnosis of pneumonia was highly significant for PCT (χ 2 106.8, P < 0.0001, AUC 0.723).

When represented as proportions of each individual study population there was a highly significant difference between the proportion of aged individuals and young individuals across GBM clinical trials (17% vs. 82% respectively, p < 0.0001) (Fig. 4 A).

Furthermore, the median survival time (TTH) of Surgicel was lower than that of Arista, PerClot, and 4DryField, and the log-rank test showed that the difference in time to achieve hemostasis between Surgicel and each of the test articles was also highly significant ( P < .0001; Supplementary Table S3 ).

A response surface analysis shows both MCPNN and MNPR have highly significant effects ( P < 0.0001) on DDTH [DDTH = 1475.34 + (147.92*MCPNN) - (148512.8*MNPR)], explaining 77.54% of the variation (Figure 2 ).

For salivary cortisol, male students exhibited a highly significant increase ( p < 0.0001) with a mean difference of 2.602 ng/mL between baseline and follow‐up samples, while female students also showed a significant increase ( p < 0.0001) with a mean difference of 2.950 ng/mL.

Notably, the region was highly significant ( p < 0.0001), with substantial variation observed across different geographic areas.

standard 5 mg versus reduced 2.5 mg twice daily) and differing proportions of dialysis-dependent versus non-dialysis advanced CKD patients across the included studies." Meta-regression confirmed that the specific DOAC agent was a highly significant moderator of bleeding risk (Q M = 22.88, p < 0.0001).