Barely Significant

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highly significantp < .00010.0× alphaqualifiedgold
There were highly significant positive correlations between DW and all genetic variation measures ( r = .729413, p < .0001, t = 6.3977), meaning that a high number of rare markers (high DW) were associated with high genetic variation.
highly significantp < 0.00010.0× alphaqualifiedgold
Our analyses identified the following variables as highly significant: “mean age,” “number of age groups”, and “data reporting quality” (all p < 0.0001). “Setting,” “disease classification,” and “number of diseases in the classification” were significant (0.01 < p ≤ 0.03), and “data collection period” and “data source” were non-significant.
a significant trendp<0·00010.0× alphagold
highly significantp<0·00010.0× alphaqualifiedgold
Analyses of tumour characteristics by year of diagnosis showed a significant trend towards lower risk tumours in more recent years, driven by a highly significant trend towards lower nodal status (p<0·0001 for both oestrogen receptor-positive and oestrogen receptor-negative groups; table 1 ; appendix p 35 ).
highly significantp = 0.00010.0× alphaqualifiedgold
5B,C , tumor growth was significantly inhibited by Trametinib exposure (p = 0.0009), while Everolimus-treated tumors did not significantly differ from vehicle control-exposed tumors in either their final size or their growth rate; however, combined treatment with Trametinib and Everolimus resulted in highly significant growth inhibition, as compared to either vehicle control (p = 0.0001) or single agent treatment (p = 0.003 for the comparison between Trametinib and combination; p = 0.0026 for the comparison between Everolimus and combination).