Excerpts

The model describing recovery rate ( rr ) was highly significant ( X 2 = 27,605,272, df = 23, P< 2.2e -16 ), with each term of the model being significant ( S2 Table ).

The 138 c-Jun-regulated genes showed a highly significant 5.8-fold enrichment (p=2.2×10 −16 ) among the 1581 genes regulated during chronic denervation.

Table 3 indicates that treatment had a highly significant effect ( F = 595.63, p < 2.2e‐16), confirming the strong impact of Striga on plant performance.

Our results indicated that 48.1% ( n = 11,422, P < 0.05) of the examined drift-CpGs exhibited a nominally significant difference (OR = 5.0, Fisher's test, P < 2.2 × 10 −16 ) between these two time points.

Considering the noisy estimates of RNA half-lives, also these modest improvements are remarkable, and statistically highly significant ( p < 2.2 × 10 −16 for all three references, t -test).

These results show, that RNAs with diminished abundances in the mutant possess a particularly high amount of cleavage sites, which was also indicated as highly significant by hypergeometric test (enrichment over background distribution of cleavage sites: 6.23-fold; p-value <2.2 −16 ).

There was a highly significant correlation ( r = 0.876, P -value <2.2 × 10 −16 ) ( Supplemental Fig.

The variance of differences for the genomic GC proportion in humans, mice, and fruit flies respectively is σ ^ n 2 = ( 0.000673 , 0.00055 , 0.00103 ) compared to σ ^ r 2 = ( 0.00469 , 0.00552 , 0.0021 ) for the permuted genome sequence, with the ratios being highly significant in all cases (F-test with p-value p < 2.2 e - 16 ).

While the p -values are highly significant ( p -value < 2.2e–16), this is likely due to the large sample size, and the relationship between TE content and gene expression is rather weak (Fig. 3 G), suggesting that genes can be highly expressed despite containing substantial intronic TE densities.

Note that likelihood ratio tests comparing the model results without and with the T1WP correction were all highly significant ( p < 2.2 × 10 − 16 ), probably due to the high number of observations and relatively small number of terms in the model.

CXCL17 was the only chemokine or chemokine receptor in the top 250 most significantly differentially expressed genes and showed a highly significant positive correlation with B7-H4 mRNA expression (Spearman Rho = 0.53; p = 2.2 x 10 −16 ) (Supplementary Figure S8).

Given that we observe 117 mutations in hypomethylated CGIs, but only expect 50.0 (117*(1/2.34*)) with the genome-wide autosomal mutation rate, this represents a highly significant enrichment (Poisson test, p = 2.2 × 10 −16 ).

This test revealed a highly significant difference in the overall distribution ( X-squared = 81.204,df = 4, P -value < 2.2e-16 ).

The Mann–Kendall trend test showed no time-dependent trend in the publication time of articles ( P =0.4654) but did reveal an increasing trend between the citation density and time ( P =2.2E-16; Fig. 3 ).

While the remaining 533 genes were induced in both cell lines, there was a significant trend toward RBM12-dependent hyperactivation ( p < 2.2 × 10 −16 by Wilcoxon signed rank test).

The results of the statistical linear regression between RSSI and the logarithm of the node-gateway distance (logD) are robust and highly significant (R2 = 0.808, p -value < 2.2 × 10 −16 , residual standard error = 10.68 dBm).

2008 ) of LMNA-associated genes identified by ChIP is highly significant ( P = 2.2 × 10 −16 , Pearson's χ 2 test).

The Spearman’s rank correlation coefficient of nucleotide diversity by gene between species was positive and highly significant for both diversity measures ( π : ρ = 0.36, P value < 2.2e-16; θ W : ρ = 0.38, P value < 2.2e-16) for a subset of 6,798 genes with these statistics available in both species ( supplementary fig.

The two-way ANOVAs demonstrated highly significant differences between the strains ( Pdyn F 1,216 = 79.25, p = 2.2×10 −16 ; Penk F 1,213 = 60.19, p = 3.54×10 −13 for the strain factor) and a significant interaction of both factors (strain x brain region: Pdyn F 3,216 = 8.79, p = 1.6×10 −5 ; Penk F 3,213 = 5.36, p = 1.4×10 −3 ).

Based on paired t -test, we showed that the exponential regression model had highly significant mean R 2 accuracy than each of the existing methods (Holsteins: t = 584.8–37281; p < 2.2–16; Jerseys: 1178.5–5861.4; p < 2.2e-16).

Kruskal-Wallis tests revealed a highly significant increase in CNVs in these epithelial tissues compared with the B cells (P<2.2×10 −16 ), indicating that they could be considered tumor cells.

The overall model was highly significant [ F (7, 3,992) = 371.3, p < 2.2 × 10 –16 ] and accounted for approximately 39% of the variance in log-transformed cattle infections.

Although the results of the test for direction of change in expression of X-linked transcripts in CDX males compared to Control males was highly significant (χ 2 = 82.7517, df = 3, P -value <2.2*10 −16 ), there was no evidence that these transcripts had feminized expression levels in CDX males ( Table 2 ).

Single marker analysis revealed that NAL1 _4_31214045 had a highly significant association with tiller number ( p < 2.2 × 10 − 16 ) and explained 22.07% of the phenotypic variance (PVE), while OFP19 _5_15069810 showed a weaker but still significant association ( p = 1.99 × 10 − 5 ), with a PVE of 3.65% (Table 5 ; Fig. 6 A, B).

These differences in seed set between the ‘selfed’ and ‘tagged’ treatments between AZ-SC and the SI sites are highly significant ( F = 128, P < 2.2e-16 for selfed; F = 110.4, P = 2.2e-16 for tagged).