Excerpts

All six models listed include cannabinoids with highly significant positive terms (from β-est. = 3.67 (2.77, 4.56), P = 3.06 × 10 –12 ) in model four) and in all six models the effect of cannabinoids is positive overall.

STRING protein interaction analysis yielded a highly significant protein-protein interaction (PPI) score (PPI score p = 8.26e- 12 ), suggesting these proteins might directly interact or work together in common pathways (Fig. 1 D).

The correlation between our CNV prediction and PCR validation was highly significant (P = 8.92E-12) (Additional file: Figure S2 ).

In Mp toc1 ko mutants, expression of Mp PRR was continuously high and arrhythmic, as indicated by highly significant effects of both genotype (G) and genotype x time interaction (GxT) terms in ANOVA ( P < 10 −11 ), suggesting that MpTOC1 represses Mp PRR .

The overall differences between the incidences of the tested neuronal markers among the virus delivered eGFP expressing neurons were highly significant, the Kruskal Wallis H test between groups: Hdf = 61.2, p < 1e − 11.

The resulting ICC(A,1) was 0.99 (95% CI: 0.0967-0.997), and the F-test confirmed that this level of agreement was highly significant (F(15, 10.6)=250, p=2.42x10 -11 ).

The accuracy T-test shows a highly significant difference (t = 14.84, p = 3.65e-11) in accuracy between M-Net and SOTA CNNs.

The two-way ANOVA (response: OD at 517 nm; factors: Treatment and Experiment) indicates a highly significant main effect of Treatment (F 2 ,12 = 319.43, p = 3.93 × 10−11), demonstrating that absorbance differs markedly among the control, thyme oil, and cinnamon oil groups.

One-way ANOVA revealed a highly significant effect of the dose group (F = 183.3, p ≈ 6.7 × 10− 11 ).

The regression model was highly significant (F = 33,119.09, p = 9.51 × 10− 11 ), with slope of 1.0150 (95% CI 1.0007–1.0293) and intercept of 1.0626 (95% CI 1.0327–1.0924), confirming statistical significance of both parameters.

In this regard, the change in CD66b expression by bound cells was highly significant, p < 10 –10 and P < 10 –5 compared to BSL and CIRC respectively (Fig. 3 c).

For each of the module, we have assigned the clinical annotation, when it is highly significant (p < 10 −10 ) and when the minimum hit of the module genes on cancer pathways is atleast 50%.

Hypergeometric enrichment analyses showed that these overlaps were highly significant ( p < 1e−10), supporting a non-random and biologically meaningful association among these factors (Fig. 3 C).

Nevertheless, a highly significant, positive correlation, was found between the qPCR and RNA-seq analyses (r = 0.91, P = 1.07 × 10 −10 ; Fig. 5e ), which supported an overall concordance between the results of the two techniques despite the low replicate number for RNA-seq analysis.

The main effect for the participant group was highly significant (F(1, 332.00) = 44.29 and P = 1.17 × 10 −10 ).

Recently, a genome-wide association scan with a subsequent replication study involving over 67,000 individuals (7,473 cases and 42,938 controls) of European ancestry produced highly significant evidence of the strong association of a single nucleotide polymorphism (SNP) rs11177 (C/T) with severe hip and knee OA ( P value = 1.25 × 10 −10 ), a missense polymorphism within the nucleostemin-encoding gene GNL3 19 .

Interestingly, we found a highly significant overlap between differentially expressed and alternatively transcribed genes in LPS response (63/150, hypergeometric test p < 2.4 × 10 −10 ), but no significant overlap between differentially expressed and alternatively transcribed genes between MDMs and IPSDMs (28/140, hypergeometric test p < 0.74).

This enrichment is highly significant (hypergeometric test followed by Benjamini–Hochberg FDR correction 33 : expected 7.5 TK, observed 24 TK, p = 3.2 × 10 -10 , FDR-corrected q = 1.9 × 10 -9 ).

6 d), with the TG association remaining highly significant even after adjustment for these metabolites (p = 4.4E−10).

gondii dataset showed highly significant improvements over ResNetKhib ( p = 6.11 × 10−10), DeepKhib ( p < 10−16), iLys-Khib ( p < 10−16), and KhibPred ( p < 10−16).

The latency of this response was faster for faces presented in the proximal than in distant condition (1467 ± 66 and 1690 ± 59 ms respectively) and this difference was highly significant (F = 52.0, p < 10 –9 , Fig. 2 C).

The changes in frequencies of each of these were highly significant (P < 10 −9 for each, remaining significant after Bonferroni correction for scanning all nucleotide positions in the genome; Table S2 ).

Among all the modules, the turquoise module showed a highly significant association with fibrosis and inflammation levels ( P = 1 × 10 −09 for fibrosis stages and P = 1 × 10 −10 for inflammation grades).

We found a highly significant non-random association of non-silent TP53 mutation to HPV negativity (Fisher’s exact test Odds Ratio = 0.14, p < 10 −9 ), suggesting an underlying association, and this was not included in the multivariate analysis.

3 c pattern, the separations between data-point distributions for all nearest-neighbor pairs of pre -transition States are highly significant in one or both of the ΔHbO 2 Sat ( p = 1.2 × 10 −9 –9.3 × 10 −4 ) or ΔtotalHb ( p = 5.5 × 10 −5 –4.3 × 10 −4 ) dimensions.