Excerpts

The difference between mean GY with two, one and zero desirable alleles was highly significant (r 2 = 0.40; p ≤ 0.000).

However, post-test comparisons revealed highly significant differences in favor of the sports subgroups ( p = 0.000 for both SOB and PI), reinforcing the positive impact of sports participation on social integration.

Comparison of the genes with no change in the stop codon, with genes with a stop codon switch reveal a highly significant increase (p < 10 −324 ) in the frequency of substitutions immediately downstream of the stop codon in genes in the latter group, suggesting compensation between changes in the stop codon and in the immediate downstream region.

The rejection of unimodality was supported by a highly significant dip test 21 (dip = 0.086275, p < 10 –293 ) using the Python “diptest” package available at https://pypi.org/project/diptest/ .

The correlation between the relative FC strength (to social-communicative-action system minus to manipulation-action system) during social-communicative-action perception and the relative activation strength (social-communicative-action perception minus manipulation-action perception) was highly significant (Pearson R = 0.48, p = 5.550 × 10 –225 , Fig. 5 a); Likewise, the correlation between the relative FC strength (to the manipulation-action system minus to the social-communicative-action system) during manipulation-action perception and the relative activation strength (manipulation-action perception minus social-communicative-action perception) was also significant (Pearson R = 0.486, p = 3.934 × 10 –231 , Fig. 5 b).

Within the brown module, a highly significant correlation was observed between gene significance (GS) and module membership (MM) (correlation coefficient = 0.92, p < 1e − 200) (Fig. 2 D).

There is a highly significant positive correlation (r = 0.709, p = 8.98 × 10 −193 ) between the expected, real IC 50 values measured in the CCLE dataset and the values predicted by regression, based on the CGP dataset, which clearly confirms the validity of the prediction framework proposed here.

We found the DHCR7 lead SNP rs2852853 interacted with cohort (P = 2.0e-02) as well as gender (P = 2.6e-03), and the HLA-DQB1 lead SNP rs9275428 interacted with cohort (P = 6.1e-04), where cohort and gender were both highly significant environmental factors in the logistic regression models based on Equation 2 in the Methods section (P < 1.0e-183 and P < 1.0e-64 respectively).

Analysis of CpG sites positively correlated across all tissues revealed ‘nervous system development’ as a highly significant gene ontology (GO) term (P = 2.0 × 10 –171 ).

All of the African populations have higher T2D genetic risk than the European populations, and the difference between the African versus European ancestry group T2D genetic risk averages is highly significant ( t = 33.9, P = 1.4 × 10 −164 ).

Using MSigDB to perform gene set enrichment analysis 26 , 27 , we found a highly significant enrichment for binding sites in the Sp1/Krüppel-like factor family 28 ( p < 10 −144 by Bonferroni-corrected hypergeometric test) and for genes downregulated in Klf1 −/− cells ( p < 10 −57 ).

The yield difference between the two basins was highly significant (t = 46.11, p < 10− 133 , Cohen’s d = -2.77), confirming the stark separation of performance states.

For example, when considering the 100 top genes most enriched in a cell type, there was a highly significant enrichment in astrocytes (Fold Enrichment (FE) = 1.4e8, p = 4.2e-103), endothelial cells (FE = 1.2e8, p = 2.8e-86), microglia (FE = 1.2e8, p = 2e-86), neurons (FE = 4.2e7, p = 3.7e-30), and oligodendrocytes (FE = 2e8, p = 6.4e-163) across the five data sets.

One-way ANOVA revealed highly significant differences in abundance, with 10 metabolites showing strong accumulation patterns (F-values 1.38 × 1031−7.84 × 1032; p < 1.03 × 10−92, FDR-corrected).

ActiveDriver identifies N-terminal mutations in five cancer types as highly significant ( n = 73, FDR p = 2.5e − 92 from ActiveDriver; Fig. 2b ), confirming constitutive activation of CTNNB1 via disrupted phosphorylation as a prevalent driving mechanism of cancer.

Results Remotely sensed data The circular-linear correlation analysis of wind speed and direction revealed a highly significant relationship, whereby stronger wind speeds are more likely to be from a westerly direction (p = 3.27*10 –80 ; Supplementary Information, Fig.

In the whole dataset, eight highly significant recombination breakpoints were identified in the genomes of the four variants cited above ( p -values < 10 −79 , Table 4 ).

Bios Consortium database found a significant methylation quantitative trait loci (meQTL) (cg03543120, p = 1.35 × 10 –8 ), and GoDMC query found five highly significant meQTLa for rs4705342 (all p < 10 –77 ) (cg00226225, cg04317047, cg03370704, cg03543120, and cg09660867).

Additionally, we have observed a highly significant difference in the expression levels of the conserved duplicates compared to the neofunctionalized (Wilcoxon test, P < 2.5E-61) and specialized genes (Wilcoxon test, P < 2.3E-42) (Fig. 5 B).

Additionally, a highly significant correlation was observed in the scatter plot of gene significance (GS) and module membership (MM) within the MEblue modules (cor = 0.92, p = 2.9e − 61) (Fig. 3 D).

This, however, was in the context of highly significant increases in average triglyceride concentrations with increasing waist circumference (P = 1.3 × 10 −56 ).

The group-mean relative signal change time course is almost perfectly correlated with the ideal response, showing a statistically highly significant association of the FAUPAs with the FT task ( R = 0.9330, P = 5.3 × 10 −56 ) (Fig. 3b ).

Discrimination capacity was high (AUC > 0.8) and highly significant ( p = 6.516 × 10 –51 ).

Ten other regions with smaller but still highly significant effects (20 ≤ − log 10 (P) < 50) were located on BTA 5 (~ 119.0 Mbp), 6 (~ 43.3, 48.1, and 85.6 Mbp), 11 (~ 103.2 Mbp), 17 (~ 50.8 Mbp), 19 (~ 60.6 Mbp), 20 (~ 55.9 and 60.8 Mbp), and 22 (~ 32.8 Mbp); these also generally affected multiple milk components.

Using 14–19 months of cumulative 24/7 home-cage activity recorded with a non-intrusive technique, evidence is here provided for a highly significant circannual oscillation in spontaneous activity (1–2 SD of the mean, on average 65% higher during peak of highs than lows; P = 7E−50) of male and female C57BL/6 mice held under constant conditions.