Excerpts

All correlation coefficients between these two datasets were above 0.99 (Pearson’s r ) and highly significant with p < 1e-5.

Notably, even after fitting the lead SNP in a conditional GWAS analysis, there were still other somewhat significant ( p < 1E–05) SNPs remaining for the HTFYslope trait (though not very strong signals; Fig. 2 ), suggesting that they could be other QTLs for heat tolerance, which were not captured by the lead SNPs identified in the study.

Although both effect sizes of PM 2.5 and PM 10 in the fully adjusted models were small (β-value of PM 2.5 = − 0.032; β-value of PM 10 = − 0.039, respectively), they were highly significant ( P -value < 0.00001).

The paired Wilcoxon test showed highly significant (p < 0.00001) Δ T core ( t ) differences between the time-dependent core temperatures T core ( t ) of the following barrel pairs: artificial zebra versus grey horse, artificial zebra vs. grey cattle and artificial zebra vs. real zebra.

The results were highly significant for all parameters (Wald χ 2 (1) < 10,000, p < 0.00001 in all cases).

The relative amino acid composition of FFS and LFS varied in accordance with DoF and the relationship was found to be highly significant (ANOVA, p < 0.00001).

For this process we filtered our complete data set by 1-way ANOVA to enrich for mass features with highly significant information ( P < 10 −5 ) in regard to the distinction of seed classes either excluding or including the colour variants of each seed type (Table S2 ; columns AV-AW).

Finally, infected C57BL/6 mice displayed a highly significant decrease in the abundance of Gastranaerophilales (Fold change = −17.96, p = 0.00001; DESeq. 2) (Fig. 6b ).

The next 2 genes (low density lipoprotein receptor ( LDLR ) and tissue inhibitor of metalloproteinases metallopeptidase inhibitor 1 ( TIMP1 ) showed moderately significant upregulation (p < 1 × 10 −5 ) in gene expression between D20+ TGF-β and D20 samples, as detected by RNASeq analysis and a significant upregulation at D20+ TGF-β vs D20 by real-time PCR (Fig. 4H,I ).

32 have shown highly significant genetic differentiation ( F ST = 0.359, P < 10 −5 ) between C . glabrata populations isolated from patients in France or Tunisia.

Enrichment for liver-relevant gene sets To provide an easily interpretable enrichment statistic, for liver-relevant pharmacogenetically important gene sets, we used logistic regression to provide natural log odds ratios at the gene level for gene set membership and the presence/absence of a nominally significant cis -eQTL or eGene ( p < 10 –5 ).

Association study Supplemental Figure s1 illustrates a highly significant correlation ( P = 0.001%) between grain filling rate and heat susceptibility index with grain yield.

In fact, highly significant ( P < 10 −5 ), down-regulated DEGs were more abundant than up-regulated ones (blue circles in Figures S3 , S4 , and S11 ).

In our study, the 2R/3R genotype was the most prevalent among Jordanian women, representing 69% of the control group and 50% of breast cancer patients—a difference that was highly significant ( p < 0.00001).

The unpaired Student’s t-test revealed a highly significant difference in PNP biodegradation between the compared conditions, with a p-value < 0.00001, indicating statistical significance well below the 0.01 threshold.

This difference between TLE subtypes was highly significant (p < 10 −5 , randomization test).

Furthermore, a robust association between observed and predicted responses for TC degradation was evident from the highly significant regression model (p-value < 0.00001), high coefficient of determination (R2 = 0.9886), and well-adjusted R2 value (0.9780) 18 , 59 .

The dF/S analysis revealed a highly significant enhancement of syx-GFP cluster formation of over 60% by vSyx (p < 0.00001, Fig. 2D ).

This difference is statistically highly significant (p < 0.00001, χ 2 -test, confidence interval: p < 0.05).

Importantly, the mean difference in allelic expression in cDNA compared with gDNA for each of the ten assays was highly significant ( P < 10 –5 ).

The chi-squared goodness of fit test showed that 46.5% (1115) of the markers significantly differed from the expected 1:1 Francis to Rondo allele ratio at p < 0.05 and 7.6% (182) of the markers had highly significant segregation distortion at p < 1e−05.

However, since there are only around 80 confirmed and 120 predicted imprinted loci in total in the human genome, the observation of even just ten of these genes in our study represents a highly significant enrichment ( P < 1 × 10 −5 ; permutation test).

Although Pd-MOF produced a highly significant downregulation of VEGFR2 gene expression in A549 cells compared with the untreated control ( p < 0.00001; Fig. 7 D), its inhibitory potency remained considerably weaker than that of the reference drug, sorafenib.

Moreover, the fluorescence intensities standard deviations differences between the groups were highly significant (W = 56,296, p -value < 0.00001; Fig. 3 b).

Statistical result interpretation The one-way ANOVA test revealed a highly significant difference in AgNPs size among the four extract concentrations (F = 98.48, p < 0.00001), indicating that nanoparticle size is strongly influenced by extract concentration.