Excerpts

In the univariate analysis age, T stage, N stage, grade and combined MMR-BRAF status were all highly significant (all p <0.001).

Furthermore when the third factor continuous light was included, the interaction between all three factors was highly significant for normalization with the selection of reference genes (p<0.001), ACT2 alone (p<0.05), but not significant when normalizing with EF1α alone ( S4 Table ).

There was a highly significant positive association (χ 2 = 19.845, d.f. = 2, p<0.001) between those who had been tested and those that knew they were contacts of COVID-19 confirmed cases, indicating government screening-testing-contact tracing measures were being carried out.

Additionally, there was a highly significant 3-way interaction (category/time-point × vaccination status × FMDV RNA load; p < 0.001): FMDV RNA load had a significant positive influence on IFN-γ and IFN-λ expression in vaccinated animals early after infection (24 hpi; p<0.01 for both), as well as on IFN-λ in non-vaccinated animals that were viremic/pre-clinical (Category II; p<0.001) ( Fig 3 ).

The difference between the two groups was highly significant (p<0.001, Student’s test, two-tailed, with Microsoft Excel) in terms of the evolution of the sequences, meaning that recent Guangxi CRF08_BC strains were more evolutionarily different from each other, suggesting perhaps that these strains undergo adaption that allows them to infect people in this locality.

We also found a very strong and highly significant correlation between the proportion of hornfels and retouched pieces in the studied sequence ( r = 0.934; p <0.001).

One way analysis of variance showed highly significant differences between all AEZs for all variables (at p < 0.001).

The overall correlation was highly significant ( r = 0.904, p <0.001, Fig 3 ).

In the period AD 1301 to AD 1550, before the transition to a dryer regime, the correlation between ENSO and rainfall variability is highly significant (r = -0.495, p<0.001, n = 240).

Our tabulated prediction accuracy (averaged over 39 subjects completing the experiment) over the full stimulus set (see Table 1 ) was highly significant for both valence (p < .001; signed rank; α = .05; h 0 : μ = .5) and arousal (p < .001; signed rank; α = .05; h 0 : μ = .5).

These changes in CA and CDCA species led to a highly significant ( p <0.001) accumulation of total primary acids (91-fold), total CA (186-fold) and total CDCA (39-fold) ( Table 1 ).

Overall, there was an increasing trend of RWE abstract acceptance from 2018 to 2020 (2018 vs 2019 vs 2020: 27.16% vs 33.6% vs 39.24%; p < 0.001) ( Table 1 ).

However, in the case of Cairns, this pattern of results was highly significant ( χ 2 ( N = 1,099, df = 1) = 12.08, p < .001, Phi = .11).

A likelihood ratio test for the hypothesis θ = 0 is shown at the bottom of Table 3 and indicates that a chi-square value of 434.66 with one degree of freedom resulted in a highly significant p- value <0.001.

The path coefficients for the path from insomnia to stress, from impulsivity to stress, from stress to anxiety, from stress to depression, from age to nomophobia, from anxiety to nomophobia and from depression to nomophobia were all highly significant (p<0.001 for all) ( Fig 2 ).

Smoking/tobacco consumption was highly significant (p < 0.001) with both anxiety and depression while moderate level physical activity and alcohol consumption were highly significant (p < 0.001) with anxiety only.

In gamergates, which have a much lower basal catalase activity, the reduction was only slight but also highly significant (statistics, see above, t = 8.37, p<0.001).

There was a highly significant main effect of phase, F (1, 52) = 51.64, p <.001, η p 2 = .50, indicating that participants committed more errors during the reversal phase ( M = 10.6, SD = 6.9) than the acquisition phase ( M = 2.9, SD = 2.7) ( Figure 1 ).

Comparison between sites using paired t-test and linear regression demonstrate a highly significant (f = 9.99; df = 44; P<0.001) difference between the Philippines site and the other four non-fished sites (vs.

Common garden experiment There was no significant effect of pond category (fish/no fish ponds) on shell shape as explained by the first principal component ( F 1, 7 = 0.06, p = 0.98), whereas there was a highly significant effect of treatment (fish/no fish cues; F 1, 7 = 467.2, p <0.001).

In 791T cells highly significant (p<0.001, 2-way ANOVA) resistance to cisplatin in hypoxia remains after transient transfection of HIF-1α short interfering RNA (siRNA) ( Figure 4E ), despite reduction in protein levels of HIF-1α and CA IX ( Figure 4F ).

The difference is highly significant (χ 2 = 54.78, df = 1, P<.001) ( Table 1 ).

Eight energy metabolism pathways (oxidative phosphorylation, citrate cycle, glycolysis/gluconeogenesis, pyruvate metabolism, pentose phosphate pathway, butanoate or propanoate metabolism, synthesis and degradation of ketone bodies, and fatty acid metabolism) and four amino acid metabolism pathways (arginine and proline, phenylalanine, tryptophan, and the aliphatic amino acids valine, leucine and isoleucine metabolisms) were identified, most of them at the three stages and highly significant ( p < 0.001; Table 2 ).

Significant differences between data sets were marked with * (low significant, p < 0.05); ** (medium significant, p < 0.01); *** (highly significant, p < 0.001).

Interestingly, a difference with respect to the HC group was already evident in the MS patients with EDSS = 0 (p = 0.049) and became highly significant starting from the group of MS patients with EDSS 1−2 (p<0.001).