First, we investigated the possible role of DRB1*03:01 in MS susceptibility and we observed a highly significant effect: OR = 1.52, 95% CI 1.23–1.88, p = 7.1*10 −5 .
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For the H3K4me3 mark, the separation at the level of PC1 = 0 was highly significant (p = 7.6x10 -5 , Fig 2A ), but not at lower PCs (see PC1 to PC5 in S3 Fig ).
SOX4 , the most proximal gene showed a highly significant association between gene copy numbers and gene expression (ρ = 0.59, p<8×10 −5 ), as did CDKAL1 (ρ = 0.78, p<3×10 −16 ).
The Student's t-test of the differences in 13 C enrichment at 20–60 min after the pulse and in the initial 13 C accumulation rate at 0.5–10.0 min showed that these differences were highly significant in both cases, p = 0.00008 and p = 0.050, respectively.
The highly significant association ( P ≤ 8.17 × 10 −5 ) between seed length to width ratio and TcSNP 733 on chromosome 5 was verified with FarmCPU ( P ≤ 1.12 × 10 −8 ).
Also, although the association between rs174548 and FADS1 was nominally significant in tissues such as whole blood and subcutaneous adipose tissue, the associations did not reach the multiple testing correction threshold (FDR<0.05, p≤ 8.30x10 -5 ).
Remarkably, PRRT2 displays a highly significant excess of nonsynonymous (pN) vs synonymous (pS) mutations in Asia (pN/pS = 4.85) and Europe (pN/pS = 1.62) compared with Africa (pN/pS = 0.26; Asia vs Africa: P = 0.000087; Europe vs Africa P = 0.00035; Europe vs Asia P = P = 0.084).
yakuba ( P = 0.0291) and highly significant for D. simulans ( P = 9.044 × 10 −5 ).
All the probes shown in Figure 2 were highly significant with p-values <9.77E −05 .
In terms of the severity of SCI, there was a decreasing trend over time for AIS grade A (P = 0.0036) and grade C (P < 0.0001), while an increasing trend was observed for grade D (P < 0.0001).
When comparing allelic frequencies between HIV-controllers and the PRIMO seroconverters, four SNPs located within the 6p21 (rs2395029, rs13199524, rs12198173 and rs3093662, are in bold in Table 1 ), showed highly significant differences (p<10 −4 ) that correspond to a striking enrichment in HIV-controllers for protective allelic variants associated with HIV-RNA levels.
= 1, p>0.35), but the interaction was highly significant (χ 2 = 20.86, d.f. = 1, p<0.0001).
A gene set/list was considered as having highly significant overlap and included in further analyses if p<0.0001, p values for the MSigdB analysis were calculated using the hypergeometric test.
The multiple regression model for color was highly significant (R 2 = 0.84, F 3,110 = 188, P <0.0001), but the slope and intercepts were affected by ecosystem type, which resulted in the following equations: (2) and (3) Despite the differences in the regression parameters, most of the color observations from the experimental ponds fell within the 95% prediction intervals associated with the regression model for natural lakes in equation 3 ( Fig. 2a ).
However, there was a highly significant intra-subject correlation between pre- and post-treatment irisin concentrations (R = 0.82, P<0.0001).
Comparatively, although we found highly significant inter-group differences (TB vs non-TB; p<0.0001;), IP-10 missed the diagnosis in ∼20% of TB patients and was falsely positive in ∼20% of non-TB patients using the AUC-derived cut-point.
The correlation between CXR results at autopsy and gross lung PA scores as calculated by non-parametric Spearman's rho (Rs) was strong (Rs = 0.75) and highly significant (p<0.0001) ( Figure 4A ).
Another risk factor duration of exposure, indicated highly significant ( P <0.0001) increase in the odds ratio (OR: 6.28; 95% CI: 2.68–14.73) when the exposure duration is high as compared to moderate.
Unpaired t-tests comparing the seronegative and seropositive populations yielded highly significant p-values (p<0.0001) for both the Immunetics® C6 Lyme ELISATM ( Fig 2A ) and the MicroB-plex Anti-C6/Anti-pepC10 Immunoassay ( Fig 2B ).
When comparing “periphery” and “interior” patterns, the difference in radial distribution of DAO-5 was highly significant (Mann-Whitney test, p <0.0001).
Overall, an increasing trend in malaria positivity was observed from 2010 to 2012 (chi-square for trend = 663.55; P<0.0001).
Highly significant increases in glutamate were noted in the CEA (p<0.0001) and BLA (p<0.0001; Fig. 6A ).
For ratings of the extent to which a speaker was being ironic, there were highly significant main effects of Statement ( F (1,32) = 87.7; p <0.0001, η p 2 = 0.72) and Occupation ( F (1,32) = 13.5; p = 0.0009, η p 2 = 0.30), as well as a significant Statement X Occupation interaction ( F (1,32) = 8.2; p = 0.007, η p 2 = 0.20), a group X occupation interaction ( F (2,64) = 4.2; p = 0.047, η p 2 = 0.11) and a significant Statement X Occupation X Group interaction ( F (3,96) = 5.0; p = 0.032, η p 2 = 0.13).
Furthermore, strain had highly significant effects on weight gain (p<0.0001), fat mass (p = 0.0002), and lean mass (p<0.0001), which did not interact with treatment ( Fig. 2A–E ).
ANOSIM detected highly significant differences in meristic counts between intensive and organic lots (R = 0.04; p<0.0001).