Barely Significant

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an increasing trendP < 0.0010.0× alphagold
The association between PLR, NLR, MLR, SII and all-cause mortality and cardiovascular mortality The Kaplan–Meier curve revealed an increasing trend in long-term all-cause mortality and cardiovascular mortality rates with higher levels of PLR, NLR, MLR, and SII ( P < 0.001, Fig 3 – 4 ).
highly significantp<0.0010.0× alphaqualifiedgold
The mean TMT showed a highly significant correlation with CSA in both groups (Spearman correlation coefficient 0.733; p<0.001), as well as in the melanoma subgroup (Spearman correlation coefficient 0.692; p<0.001) and lung cancer subgroup (Spearman correlation coefficient 0.767; p<0.001) separately.
highly significantP<0.0010.0× alphaqualifiedgold
The FT-AT AUROCs predictive values for survival without HBV complications were still highly significant after exclusion of 16 patients with FT high-risk profiles of false positives/negatives (n = 1,058 AUROC = 0.88, 95%CI 0.81–0.92; P<0.001), Impact of HBV treatment on biomarkers Among the treated patients, the first FT has been performed in 276 patients before treatment and among 370 patients during or after treatment.
highly significantp <0.0010.0× alphaqualifiedgold
2C shows a moderate but highly significant constitutive IFN-β expression and IRF-3 activity -but no NF-κB activity (not shown)- in WT RIG-I-transfected cells (n = 3, p <0.001 when compared to control vector-expressing cells), in agreement with the fact that RIG-I is especially prominent in signaling pathways leading to type I IFNs [2] , [3] , [4] , [15] .
highly significantp<0.0010.0× alphaqualifiedgold
Highly significant effects of time (p<0.001) were detected for each trill feature ( Fig 8 ) except for trill entropy where a significant effect only was observed (p<0.05) and for the trill mean interval duration that did not change with time (p = 0.1903).