Excerpts

Because the correlation between the two ROIs was positive in every subject, the group-level statistic was highly significant (sign test, p < 5 x 10 −15 ).

Notably, highly significant GO terms included skeletal system development (p = 6.1e-15), collagen fibril organization (p = 1.5e-15), extracellular matrix organization (p = 5.8e-13), and roof of mouth development (p = 4.7e-13).

Inversely, a statistically highly significant DEHP-induced decreased reads numbers (p = 9*10 −15 ) was observed in Tmem125 promoter region in MBDseq experiment in C57BL/6J controls (19.8±3.9) compared with DEHP300 (0.9±3.9%), ( Fig 5B ), consistent with a DEHP-induced decreased methylation levels recorded in pyrosequencing experiment in CpG 1 although not statistically significant (p = 0.7) in C57BL/6J controls (69±4%) compared to DEHP300 (65±10%), ( Fig 5C ).

Highly significant differences were detected between calculations using Phylomatic and the unconstrained (t = -9.7575, df = 69, p-value = 1.271e-14; t = -14.686, Barocode only: df = 67, p-value < 2.2e-16), as well as the constrained (t = -12.365, df = 69, p-value < 2.2e-16; Barcode only: t = -17.857, df = 67, p-value < 2.2e-16) barcoding ML analyses ( Fig 5 ).

As expected, the Nrf2/Keap1 pathway genes were highly significant (p = 1.8×10 −14 ).

While these showed highly significant association ( p = 4.05×10 −14 for both markers) in the control group, in the temperature treated group neither marker was significantly associated after correction for multiple testing ( p = 0.039 for both markers).

Another protein with a molecular size of 8766 m/z also showed a highly significant difference ( P = 4.35×10 −14 ) between pancreatic cancer patients and healthy controls ( Fig. 2 , indicated by quadruple asterisks).

We found a highly significant strain effect ( F 1, 60 = 96.28, p = 4.4×10 −14 , η p 2 = 0.616), a significant sex effect ( F 1, 60 = 11.44, p = 0.0013, η p 2 = 0.160), and no significant interaction effect ( F 1, 60 = 0.04, p = 0.84, η p 2 = 0.001) using a two-way ANOVA on transformed in-cage activity.

Using a Fisher's exact test this difference was highly significant ( p = 4.8*10 −14 ).

Community 1 contains all of the centromeres, so not surprisingly it has a highly significant enrichment for centromeres (p = 9.36e-14).

We found that the participants’ correlation coefficients were highly significant in the individual level and in the group level (average R = 0.26 in experiment 1, p = 10 −13 ).

Our risk score analysis using the sum of all 54 (both genotyped and well imputed) GWAS-significant risk alleles as a predictor of T2D risk in the Singapore Chinese Health Study population, while highly significant statistically (p<10 −13 ), showed per-allele ORs that are smaller on average (1.05) than the mean (1.16) of the published ORs for these alleles or of the mean (1.07) of the single SNP ORs estimated in this study.

The differences between T1D and control subjects are highly significant in both male (p<10 −13 ) and female groups (p<10 −13 ) ( Figure 3b ).

Among the KEGG results, the most highly significant pathway overlap was between MS and RA (P = 1.03E-13), followed by T1D-RA (P = 51.22E-12), T1D-Alz (P = 5.91E-11), MS-T1D (P = 8.58E-10) etc.

The p -value reported by the Friedman test is still highly significant ( p < 1 ⋅ 10 −13 ), but Shaffer’s static method could only separate the classifiers into two groups.

aegypti ITS1 T p against the natural logarithm of overall DNA concentration was found to be highly significant (p = 1.2 e-13) with an adjusted R 2 of 0.918 and a regression coefficient of -1.391 (S.E. 0.086).

This difference was highly significant (t = 12.58, p = 1.7154E-13) and was associated with an exceptionally large effect size (d = 3.68).

A weak ( r = 0.219) but highly significant ( p = 2.23×10 −13 ) correlation between expression of SOX2 and SOX2OT was found ( Figure 1 ), emphasizing the potential importance of this signaling pathway in human breast cancer.

The reduction of RUNX1 expression in high-grade tumors is highly significant (p-value = 3×10 −13 for the Ivshina dataset and p-value = 2.5×10 −9 for the Lu dataset by linear regression model analyses).

Once again an F-test was performed, looking for an effect of disease status in the presence of age and study site and allowing for an interaction between disease status and age; the result was highly significant (p = 4 x 10 −13 ).

This difference in proportion Metazoan is highly significant (P = 6.91×10 −13 , Fisher's Exact Test); induced genes are also much more likely to be wasp-specific (31.3% induced, 16.3% other genes, Fisher's Exact Test P = 8.85×10 −7 ).

The difference in substitution scores between core and surface region is highly significant for both SVD and CSM ( P <1.0 −12 ) and significant for SVP ( P <1.0 −4 ), whereas it is not significant for SAP ( P <0.78).

The TPT main effect was highly significant regardless of the data set used (full data set: F 10,370 = 37.6, p<1×10 −12 ; limited data set: F 10,370 = 30.7, p<1×10 −12 ), clearly indicating the significance of the online compensatory adjustments of F1 in response to the AF perturbations when the data were collapsed across the two groups of subjects.

Of the 119 genes that were both represented in the MCF-7 dataset and increased in EGFR -mutant NSCLC cells, 44 (31%) were increased with P <0.05 in EGFR -transfected MCF-7 cells, which represented a highly significant overlap ( P <1E–12, one-sided Fisher's exact test, Fig. 2 E ).

Results The differences in the distribution of SE between the wake and N2, and wake and N3 were highly significant ( p < 10 − 12 for both comparisons), whereas the difference between the wake and REM states was not ( p = 0.12 ).