Excerpts

rs35346340 is a significant FURIN eQTL in esophageal mucosa ( P = 2.0E-13) and a nominally significant eQTL of this gene in aortic artery ( P = 1.0E-04), and FURIN is highly expressed in both primary and immortalized cardiac fibroblasts.

But given the number of phonemes presented to the participants, our results are highly significant: all p < 10−4.

1a ), supra-threshold amplitudes of wave I of the ABR (in response to 50-μs clicks) remained low and showed significantly shallower growth with sound intensity, compared to pre-exposure values (repeated measures analysis of variance (ANOVA) for pre-exposure and 4-week post-exposure data showed a significant effect of group, p = 0.043, and a highly significant interaction between time of measurement and sound intensity, p = 0.0001; Fig. 1b ).

Pairwise comparison of matched cancer and normal adjacent control tissues from individual patients revealed a highly significant increase in proportion scores in cancer tissue ( P <0.0001, Wilcoxon's signed-rank test; Fig. 7f ).

Permutation tests (see the “Methods” section) indicated that observing 15 concordant features is statistically highly significant, exceeding all 10,000 random permutations ( p < 0.0001, Fig. 8b ).

Infant RM are typically weaned between 6 and 9 months of age and at the 6 month time point, there was a highly significant inverse correlation between dorsal length and K/T ratios ( P < 0.0001) and this correlation was also observed at 9 and 12 months of age ( P = 0.004 and P = 0.04, respectively, Fig. 6a ).

ns, p > 0.05 , not significant; p ≤ 0.05 , significant; p ≤ 0.01 , very significant; p ≤ 0.001 , highly significant; p ≤ 0.0001 , extremely significant.

There are also highly significant associations with measures of nuclear grade including nuclear membrane irregularity, ( p < 0.0001), nuclear size ( p < 0.0001) and nucleolar size ( p < 0.0001) (Fig. 5d ) and with high-risk histological patterns of disease (Fig. 5e ).

This distribution of alternative and constitutive pG4 genes for each UTR context was found to be highly significant through permutation testing ( P value < 0.0001 for 5′ and 3′ UTRs).

A linear regression analysis showed a very good correlation ( R 2 = 0.924) between the HrOr263 hydrocarbon responses in the ab3A and ab2A neurons, which was highly significant ( p < 0.0001).

In contrast, PD-1 blockade resulted in highly significant tumor growth delay ( p < 0.0001) in all mice bearing Nedd8 KO EO771 tumors (Fig. 6b ).

This analysis revealed a highly significant positive correlation (R 2 = 0.76; p < 0.0001) between the two scores in tumours, suggesting that both biological characteristics are present simultaneously in the same samples, rather than being averaged across them (Fig. 4d ).

Both the model based on Ad26.COV2.S and the model based on all vaccine candidates have highly significant slopes ( p < 0.0001) in the nose.

Post hoc pairwise comparisons following highly significant Kruskal-Wallis test ( p -value < 0.0001) revealed four major groups reflecting significantly different PC distribution patterns within the ML (Fig. 7c ): ordered monolayer (group I), ordered multilayer (II), scattered multilayer (III) and totally scattered (IV).

The Kaplan–Meier curve, however, does show a highly significant trend of loss-of-barrier function at higher concentration ( P < 0.0001 for both curve difference and trend significance, derived from log-rank tests) (Fig. 4i ).

Likewise, BEAF + and CP/CH + boundaries on chrX show a highly significant difference in insulation between males and females (Wilcoxon test p -value < 10 −4 ) (Fig. 4e and Supplementary Fig. 8e ).

The difference in the survival rates between genotypes is highly significant with values of P < 0.0001.

The linear correlations of L ↓ and K ↓ with T are highly significant ( p < 0.0001) for all the five reanalysis products.

Considering the set of GO terms that are highly significant in snRNA-seq (adjusted p -value < 0.0001), 42 out of 47 GO terms identified that were also significant in proteomics (adjusted p -value < 0.05) had the same direction of up/down-regulation.

Although the interaction was not significant, post hoc simple effect analyses confirmed that the aforementioned trend was highly significant in prefrontal cells (simple effect of cycle, F 3, 2244 = 11.3, P < 10 −4 ), with inferior parietal cells showing a similar but more moderate trend ( F 3, 2244 = 3.32, P = 0.02).

All these differences were highly significant (pairwise two-tailed t-tests, P<0.0001).

This correlation was highly significant, far higher than the maximum correlation observed in randomized comparisons (empirical P < 0.0001; N = 10,000 bootstraps, R max = 0.03, see Methods).

2d ), we used gene set enrichment analysis (GSEA) to demonstrate a highly significant enrichment (nominal P -value <0.0001) of this set within AST as compared with NAS neurons ( Fig. 5e ).

In addition, all measurements of Q A redox state and g s in all lines could be described by a single highly significant positive correlation ( P < 0.0001, ANOVA; Fig. 1h ), consistent with a role for Q A redox state as an early determinant for stomatal opening in response to light intensity 17 .

The main frequency effect was highly significant ( F 3,24 = 41.10, P < 0.0001).