II), genotype, and epithelial zone yielded a highly significant difference for HC type ( F (1,46) = 1348.33, P = 0), but for no other comparison.
Excerpts
These differences are highly significant (Z-test p = 0).
Finally, introns and lincRNAs have a more tolerant gwRVIS score distribution that more closely resembles the distribution from intergenic regions, but due to the sheer size of the corresponding score lists the divergence remains highly significant (median scores: −0.050, −0.0015; Mann–Whitney U vs. intergenic: p < 1 × 10 −308 and p = 2.6 × 10 −168 , respectively).
These included four differentially methylated CpGs associated with eGFR; a highly significant cg21961721 within SLC27A3 ( p < 2.2 × 10 −308 ), two intergenic CpGs between ZNF788P and ZNF625-ZNF20 (cg17944885; p = 3.7 × 10 −13 and cg25544931; p = 2.1 × 10 −5 ), and cg05165263 within the IRF2 gene ( p = 6.6 × 10 −5 ).
In terms of p-value, 25 out of 58 tests are nominally significant ( p < 2.2 e − 308), with 6 out of 58 being significant after adjusting for 58 tests, including variants in TCF7L2 and age for Glycated hemoglobin (HbA1c), variants in SMOX and sex for High light scatter reticulocyte count, Reticulocyte percentage, and Immature reticulocyte fraction, variants in CSP1 and sex for Mean platelet (thrombocyte) volume.
22A ) and revealed a highly significant correlation of effect sizes (Spearman’s rank correlation) between both types of variants ( r = 0.85, P < 2.2E−308).
Prior to pleiotropy test, analysis of genetic correlation between the traits showed a highly significant genetic correlation between t-tau and p-tau181 ( p = 6.99 × 10 −303 ), however, correlation of these two traits with Aβ42 was not significant (p Aβ42 vs t-tau = 0.25 and p Aβ42 vs p-tau181 = 0.27).
This resulted in highly significant two-sided p -values in all cases (always p < 1E-300).
At enhancer sites, CTBP2 peaks, as well as HDAC3 peaks, demonstrated a highly significant overlap with the TRPS1 peaks that we identified in our previous experiments in MCF7 cells ( P = 4.28 × 10 −268 for CTBP2; P = 6.08 × 10 −53 for HDAC3).
However, the predicted expression results for the discovery case samples that used the normal thyroid reference data showed a highly significant association ((additive model of linear regression) P =2.99 × 10 −244 , Fig. 2c and Table 2 ).
Among the 12 genes related to hormone secretion, Vgf (nerve growth factor inducible) showed a highly significant increase in expression in GCGR-KO α-cells (Log 2 FC = 1.38; p = 2.21E-203) (Fig. 4a ).
After controlling for read depth, we identified a highly significant enrichment of eQTLs among our ASEs ( p value = 2.65 × 10 −195 in putamen and 9.99 × 10 −111 in substantia nigra, using a randomisation approach—see Online Methods).
Partial correlation analysis performed on the INO80 ChIP-seq and DRIP-seq data over RNA-seq data, indicated that the correlation between INO80 and R-loop enrichments remained highly significant when controlled for gene expression levels ( p = 5.5 × 10 −160 , Supplementary Fig. 10a–c ).
In both cases, we found it to be highly significant (R = 0.92, p -value = 4.15 −151 for DNA and R = 0.98, p -value <8.7*10 −286 for RNA, Fig. 1d,e , respectively, Supplementary Data 2 ).
\usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\bar{w}\left({n}_{{wt}}\right)=$$\end{document} w ̄ n w t = 0.48, a difference that is highly significant ( P = 3.8 × 10 −148 , two-sided Mann–Whitney U = 43,750, n = 681).
The precision of this alignment was further quantified, showing a 74.5% overlap between high-risk and tumor cell categories, with McNemar’s test 84 demonstrating a highly significant association ( P = 3.54 × 10 −146 ) (Fig. 5 d), thereby supporting SIDISH’s accuracy in identifying cellular drivers of poor prognosis within their spatial context.
SUPPA2 identified 2576 events from 1482 genes, with a highly significant overlap in differentially spliced genes between the two approaches ( P = 10 −120 ; Supplementary Fig.
P values were highly significant ( P <1 × 10 −112 ).
Using a subset of 19 metrics, MANOVA analysis revealed the there was a highly significant difference in the structure and dynamics of the plant ER under these treatments (Pillai’s trace, F (72,648) = 17.5, p = 2.7 × 10 −110 ; or Roy’s largest root, F (18,162) = 36.7, p = 7.9 × 10 −48 ).
Among these, MTND2 had highly significant associations across HDL cholesterol, Apolipoprotein A1, LDL and Triglycerides (lowest P = 3.2 × 10 –103 ).
We also confirmed strong and highly significant associations at the previously described loci, including chromosome 2q24.2 encoding PLA2R1 (rs17831251, OR = 2.25, Meta-analysis P = 4.7 × 10 −103 ) and 6p21.32 encoding HLA-DQA1/DRB1 genes (rs9271573, OR = 2.41, Meta-analysis P = 2.7 × 10 −154 ).
This highly significant overlap ( p -value = 4.3 × 10 − 102 by hypergeometric test, 2.4-fold-enriched) demonstrates that alteration of regulatory complex binding is strongly predictive of a change in gene expression (i.e., 70%; 359 / 510) and suggests possible mechanisms for the observed gene expression effects.
Similarly, when surveying combined protein expression and SV data across 328 cell lines 38 , 54 , 55 , we observed a highly significant overlap ( p < 1E−100 chi-square test) of events involving CRISPR knockout effect in genes with events involving SV-associated protein over-expression (Fig. 8b ), involving 2682 genes, 178 with combined breakpoint and protein over-expression involving at least 5% of cell lines examined (Supplementary Dataset 10 ).
3c , upper panel; n = 3365; median CO = 0.68, IQR = 0.46–0.82), and the difference in median CO between positively responsive cells and the entire population of segmented cells ( n = 24,540; median CO = 0.44, IQR = 0.23–0.70) was highly significant ( P < 10 −100 , Wilcoxon rank-sum test).
For instance, the enrichment of EGR1 binding sites on hypomethylated regions in excitatory-neuronal subtype mL4 is highly significant (odds ratio: 1.7, Binomial test, p -value = 6.7e-83).