For functional disability outcomes, the 8 min protocol demonstrated a highly significant overall advantage (LME estimate: −12.84, 95% CI: −19.36 to −6.32, p < 0.001).
Excerpts
Inflammatory and Thrombophilia Markers, Angiographic Distribution, and Treatment Outcomes Inflammatory activity, measured by ESR, was significantly higher in stroke-positive Takayasu patients (50.6 ± 11.4 mm/h) compared to stroke-negative cases (26.3 ± 10.6 mm/h) and controls (22.4 ± 8.4 mm/h), indicating a highly significant difference ( p < 0.001).
Results : The analysis showed a decreasing trend in hospitalizations of patients with STEMI (Z = −3.574; p < 0.001) and an increase in hospitalizations of patients with NSTEMI (Z = 3.124; p = 0.002).
Zone-specific analysis revealed highly significant differences in coverage across anatomical regions (Friedman chi2 = 450.12, p < 0.001).
There was a highly significant association between polyposis syndrome status and histopathological subtype (χ 2 = 58.7, p < 0.001), with adenomatous and hamartomatous lesions predominating in syndromic patients, whereas juvenile and inflammatory polyps were almost exclusively observed in non-syndromic cases ( Table 4 ).
Our analysis revealed a highly significant ( p < 0.001) association between the expression of the Thomsen-Friedenreich (TF) antigen and MSI status.
Based on the results of the Cochran–Armitage test for trend, there was an increasing trend in ICR between the three groups ( p < 0.001) ( Table 2 ).
Results for Adverse Events The prevalence of experiencing at least one AE was significantly higher in the combination therapy group (0.9322, 95% CI: (0.9111, 0.9534)) than in the monotherapy group (0.8194, 95% CI: (0.6562, 0.9152)), with a highly significant difference ( p < 0.001 ).
There was also a significant trend ( p < 0.001) for increased plaque volume with increasing number of vascular beds involved (median of 393 mm3 (IQR: 166–691 mm3) for 1 vascular bed vs. median of 657 mm3 (IQR: 339–1036 mm3) for ≥2 vascular beds ( Figure 2 ). 3.3.
However, sensitivity analyses using worst-case imputation (assuming no improvement for all patients with missing data) confirmed that primary findings remained robust: NPRS results remained highly significant ( t = 28.58, p < 0.001) and SANE results likewise remained significant ( t = 23.77, p < 0.001) under this conservative assumption.
All preoperative-to-postoperative group differences were highly significant ( p < 0.001).
The test results showed a highly significant difference among the groups (H = 83.53, p < 0.001), as detailed in Table 3 indicating that we can reject the null hypothesis.
There was a highly significant improvement from the preoperative stage to the last follow-up for all values ( p < 0.001).
Internal Validation and Model Diagnostics The multivariable binomial logistic regression model constructed to evaluate 12-month mortality demonstrated an excellent overall fit (Deviance = 358, AIC = 370, BIC = 393, McFadden’s R 2 = 0.228) and was statistically highly significant (Omnibus likelihood ratio test χ 2 = 106, df = 5, p < 0.001).
Across the five years the association between sex and disease occurrence was highly significant for the major comparisons (all overall p < 0.001).
Infection resulted in a highly significant total indirect effect on the long COVID phenome (t = 8.92, p < 0.001).
On the first day after surgery a highly significant ( p < 0.001) decrease by 33.68% to 27.61 ± 12.55 μmol/L at T2 ( Figure 2 ) was observed.
Finally, age was negatively associated with temporal orientation across all groups, with highly significant relations (all p < 0.001).
This increase in primary implant utilization from ~40% to ~70% of cases is highly significant (χ 2 , p < 0.001).
For RCII, the association was stronger and more consistent: per SD increase (OR 1.23, 95% CI: 1.00–1.51, p = 0.046) and Q4 (OR 5.20, 95% CI: 2.24–12.08, p < 0.001) both showed significant independent associations, with a significant trend across quartiles ( p < 0.001).
NT-proBNP Reflects Hypertrophy Rather than Dilatation or Dysfunction Highly significant correlations were found for interventricular septal thickness (LVH, r = 0.678; p < 0.001 vs. no LVH, r = 0.243; p = 0.276, Figure 3 A,D), left ventricular maximum wall thickness (LVH, r = 0.717; p < 0.001 vs. no LVH, r = −0.227; p = 0.502, Figure 3 B,E) and left ventricular mass index (LVH, r = 0.549; p < 0.001 vs. no LVH, r = 0.184; p = 0.298, Figure 3 C,F).
The risk score also showed a significant trend for in-hospital mortality in the validation cohort ( p < 0.001) ( Figure 2 B).
Analysis further shows that there was a positive trend of increase of the prevalence of CFA positivity with increasing age ( χ 2 = 53.83, p < 0.001), with a maximum of 10.2% being among age group of 65+ years.
The resistance rate of cefepime decreased from 9.4% to 4.8%, showing a decreasing trend year by year ( p < 0.001).
However, our findings indicate a notable trend: viral infections were significantly more likely to be associated with recurrent episodes of keratitis (31.33% vs. 19.91%, p = 0.001), whereas bacterial infections more frequently accounted for first-time episodes (47.00% vs. 38.63%, p = 0.001).