Barely Significant

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highly significantp < 0.0010.0× alphaqualifiedgold
There was a highly significant association between polyposis syndrome status and histopathological subtype (χ 2 = 58.7, p < 0.001), with adenomatous and hamartomatous lesions predominating in syndromic patients, whereas juvenile and inflammatory polyps were almost exclusively observed in non-syndromic cases ( Table 4 ).
highly significantp < 0.0010.0× alphaqualifiedgold
According to the cut-off value determined by ROC analysis for SII, median PFS was 5 months (95% CI, 2.94–7.06) in the low SII group and 4 months (95% CI, 2.79–5.21) in the high SII group, showing a highly significant difference ( p < 0.001).
highly significantp < 0.0010.0× alphaqualifiedgold
This epitope was almost exclusively located within neurons and an intensity correlation for co-localization confirmed this observation, demonstrating a highly significant percentage of neurons co-labeled with NeuN compared to both Iba1 ( p < 0.001) and GFAP ( p < 0.001) immunostained cells ( Figure 10 D). 4.
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Accordingly, patients with a deterioration after initiation of treatment showed a massive and highly significant ( p < 0.001) worsening in the FVC slope (right panel, right part), as compared to the similarly significant ( p < 0.001) slight improvement in the FVC decline in those patients stable upon initiation of pirfenidone treatment (left panel, right part).
highly significantp = 0.0010.0× alphaqualifiedgold
Our analysis revealed the following significant correlations between VA and satisfaction or frequency of spectacle use: A moderate positive correlation (rho = 0.635) exists between UDVA and satisfaction without spectacles at far distance, with a highly significant p -value ( p = 0.001); we also observed a moderate negative correlation (rho = −0.412) between UDVA and the frequency of use of spectacles for medium distance, with a statistically significant p -value ( p = 0.041).
highly significantp = 0.0010.0× alphaqualifiedgold
Among the evaluated covariates, baseline sagittal jaw relationship (ANB) emerged as a highly significant independent predictor (beta = 0.36, 95%CI: 0.151 to 0.573, p = 0.001), indicating that patients presenting with more severe initial sagittal discrepancies experienced a greater magnitude of forward maxillary change.
highly significantp < 0.0010.0× alphaqualifiedgold
Subsequently, the prognostic relevance of the three XBETA-based risk categories was assessed using Kaplan–Meier survival curves, which demonstrated a highly significant separation between groups (log-rank χ 2 = 102.441; p < 0.001) ( Figure 4 ).
highly significantp < 0.0010.0× alphaqualifiedgold
A strong temporal trend in prescribing was observed: the proportion of patients discharged on SAPT was 10.1% in the pre-2020 era (45 of 447) and 47.4% in the 2020–2023 era (102 of 215); the χ 2 test for the era-by-regimen association was highly significant (χ 2 (1) = 117.4, p < 0.001). 3.3.