Excerpts

The difference between the mean radiation-induced G2 scores for 0.05 Gy compared to 0.5 Gy in this cohort were highly significant (two-tailed p value < 0.0001) by the Mann–Whitney test and this is also illustrated in Figure 1 for both doses in the healthy control donors.

The effects on wound closure at 24 h has shown that LMWHA + Secre and MMWHA+Secre solutions is highly significant ( p < 0.0001) compared to CTR, LMWHA and Secre.

Upregulation of miR-132-3p led to a small, but consistent, enhancement of NMT2 expression (118%) whereas down-regulation of miR-132-3p was associated with a highly significant decrease in NMT2 expression (39%) ( p = 0.0001).

This was a highly significant difference ( p < 0.0001) compared to the age-matched hSOD1-WT mice ( Figure 6 B).

Concerning p -values, the results were highly significant for the protein when stored at 4 °C for all the tested conditions ( p -value < 0.0001), and significant when the protein was stored at −80 °C ( p -value < 0.05 and p -value < 0.01).

Thus, ANOVA showed a highly significant line × FS interaction ( p < 0.0001; Table 2 ) and notably, pairwise post hoc contrasts revealed that the basal level of BDNF-LI of RLAs was markedly lower (−69%) than that of the RHAs ( p < 0.0001; Figure 3 ).

A strong and highly significant correlation was observed between plasma and PBMC-expressed SDC3 levels ( r = 0.921; p < 0.0001).

ASA concentrations > 1000 μM (10,000 μM and 16,000 μM) impaired the mitochondrial metabolic activity, which is equivalent to aerobic cellular respiration, revealing highly significant differences in comparison to the remaining concentrations after 3 (16,000 μM: p < 0.0001–0.01) and 7 (10,000 μM and 16,000 μM: p < 0.0001) days of cell culture with a visible decrease in their respective RFUs.

Although the correlation between the miR-320 family members and the number of neutrophils just missed significance, neutrophilic miRNAs, miR-142-3p ( p < 0.0001, r = 0.5679) and miR-223-3p ( p < 0.0001, r = 0.6496), significantly correlated with neutrophil counts in our patient cohorts ( Figure S1 ). 3.

Only the experimental group of combined CIP with PIC maintained a highly significant difference ( p < 0.0001) within 24 h for these two strains.

Once again, highly significant differences ( Table S6 ) were detected in the colon levels of LTB4 at the different time points ( p < 0.0001 for no DSS vs. 5 days of DSS treatment; p < 0.0001 for 5 days DSS treatment vs. 10 days after DSS removal).

A highly significant impairment of cell viability, corresponding to a 74% reduction compared to the untreated cells ( p < 0.0001), was observed in 100 μM H 2 O 2 -treated cells, in agreement with the study of Ghaffari et al.

All regressions were highly significant ( F -value = 352.31, and p -value < 0.0001 for CLD % and F -value = 276.91, and p -value < 0.0036 for TS), and also the R 2 coefficients were adequate (0.988 for CLD %, and 0.998 for TS), demonstrating the models are suitable for representing the responses.

The addition of R428 to RTX treatment resulted in a highly significant decrease in colony formation capacity in the SF126 cell line ( Figure 4 A, ordinary one-way ANOVA, SF126: **** p < 0.0001).

Standard resazurin-based drug sensitivity assays showed that as expected, TbAT1 expression caused a highly significant sensitization to tubercidin ( p < 0.0001) in three independent clones ( Figure 10 ), as tubercidin is a good substrate of TbAT1/P2 [ 46 ] but at best a poor substrate for the T. congolense adenosine transporter, TcoAT1 ( Table 6 ) and as a result tubercidin is a relatively poor agent against T. congolense ( Table 8 ). 2.4.4.

In the case of the SKOV-3 cell line, with high HER2 expression, a saturation of HER2 with an excess of unlabeled proteins resulted in a highly significant ( p < 0.0001 in unpaired t -test) reduction of binding of both proteins.

Fumarate levels showed a highly significant decrease ( p < 0.0001), while succinate levels were also significantly lower ( p = 0.005) in both strains following treatment ( Figure 9 D).

The differences across these groups were highly significant ( p < 0.0001), indicating a positive correlation between MIF levels and disease severity.

These results were independent of LPS stimulation, and the differences against control experiments were highly significant ( p < 0.0001). 2.5.

GDF-15 showed the most robust response, with highly significant main effects for both time and dose and a strong interaction ( p < 0.0001).

Both 1 μg/mL and 5 μg/mL treatments led to a highly significant increase compared to untreated controls ( p < 0.0001) ( Figure 4 D).

The distance differences were statistically highly significant ( p < 0.0001) ( Figure 3 F).

The difference between average ΔF/F MAX of WT (0.084 ± 0.017) and MUT (0.019 ± 0.004) rods was highly significant (*** t = 4.40122 with 32 df: p = 1.12099 × 10 −4 ).

10 4 /mL blood), intriguingly, CD33 and CD64 showed a highly significant inverse profile in this study ( p = 0.00012; Figure 3 A right).

The difference between the figures of the MWT values obtained from control and CFA-treated rats was highly significant ( p = 0.000125).