Excerpts

The overall effect of the IIRC grouping was highly significant ( p < 0.0001) ( Table 3 ).

By correlating the immunohistochemical results with clinicopathological data, we demonstrated a highly significant correlation of NRF2 high and AKR1C3 high tumors with worse overall survival (OS) ( p < 0.0001 and p < 0.001, respectively) ( Table 1 and Table S1 ).

However, based on tumor grade, the decrease in HADHA transcript level is not significant (ns, p = 0.999) between normal and grade 1 tumors but it is highly significant between normal and grade 2 ( p < 0.0001) and 3 ( p < 0.001) tumors. 3.2.

Similarly, the percentage of positive fields for IL-13Rα2 expression in 2+ and 3+ positive specimens in IHC analysis demonstrated a highly significant trend in these specimens (well differentiated = 35.0%, moderately differentiated = 82.0% and poorly differentiated = 94%; exact p < 0.0001) compared to PDAC samples with negative values of IL-13Rα2 (≤ 1+) ( Figure 1 D).

MRND yielded a highly significant difference (1.40 ± 0.42 vs. 6.16 ± 1.0, p < 0.0001). 3.3.

It was found that the difference between the arithmetic means was statistically highly significant ( p ≤ 0.0001) Table 1 .

The test confirmed highly significant separation (global log-rank p < 0.0001).

The results in Figure 8 show a highly significant correlation between the potency of both compounds in the cancer cell lines, with an R -value of 0.852 ( p < 0.0001 ).

As shown in Figure 2 a,b for the universal assay, we found a highly significant correlation (R 2 = 1.000, p < 0.0001 without; R 2 = 0.998, p < 0.0001 with added third-party DNA) between the numbers of HCK and axi-cel copies up to the lowest concentration.

The primary patient-derived xenografts used for this study displayed a wide range of tumor hypoxia (1%–39%) that was highly significant ( p < 0.0001), whereas there was relatively little variance in the levels of hypoxia within replicates from the same model ( Figure 1 A).

We are the first to report on a highly significant association between HER2 overexpression and/or amplification and the p53abn molecular subgroup ( p < 0.0001) with 95.8% of HER2-positive EC classified in the p53abn subgroup in the PORTEC-3 HREC.

As shown in Figure S1a , HER2 mRNA expression levels among different patients exhibited highly significant correlation in the analyses by microarray and qRT-PCR (r = 0.94, p < 0.0001), validating the heterogeneous expression of HER2 mRNA in primary HER2-positive BCs.

For discrimination of patients with metastasized NEN from presumably cured NEN patients, the combination of cfDNA concentration, hypomethylation, and cfDNA integrity revealed a highly significant AUC of 0.908 (95% CI, 0.83 to 0.99; p = 0.0001) with a positive predictive value (PPV) of 91.1% and negative predictive value (NPV) of 66.7% at the chosen classification cutoff of 0.5 ( Figure 4 B).

obese was highly significant, **** p < 0.0001, whereas obesity-resistant vs . obese was also highly significant (**** p < 0.0001, TMCT), and no significant differences between lean and obesity-resistant mice were observed (ns, TMCT).

In addition, these remained highly significant after exclusion of outliers ( r = −0.525, p < 0.0001 and r = −0.507, p < 0.0001, respectively; Figure 2 b).

Highly significant differences between adjacent and tumor tissues were found by statistical analysis using the Mann–Whitney U test ( p < 0.0001 for all comparisons; Figure 2 A–C).

The median OS for the PDS group was nearly double that of the IDS group, with a highly significant difference of 52.0 months versus 27.5 months (log-rank test, p < 0.0001). 4.

This upregulation was statistically highly significant ( p < 0.0001) ( Figure 3 ).

We analyzed the expression of PD-1 on T cells ( Figure 4 E) and detected highly significant increased frequencies of PD-1-expressing CD8+ and CD4+ T cells in the tumor ( p < 0.0001).

In the multivariate proportional hazards regression model that included IDLE, TNM staging, tumor grade, and the potential confounding variables (age at surgery, chemotherapy, and radiotherapy received either before or after the surgery) ( Table 2 ), both TNM staging and tumor grade lost statistical association with cancer progression ( p > 0.63) when IDLE was included in the model, while the association of IDLE with progression was highly significant (HR = 5.671, 95% CI = 3.1650–10.1605, p < 0.0001).

Similarly, the comparison between 2020 and 2023 showed highly significant differences ( p < 0.0001).

The according risk of developing oral cancer was 0.65% and 0.18%, whereby the risk difference of 0.47% was highly significant ( p < 0.0001; Log-Rank test).

Tests of equality of group means showed that the increase in the number of CD8+ cells and IFN-γ expression levels in irradiated tumors were highly significant ( p < 0.0001), and that either measure was 100% accurate in predicting treatment response.

Kaplan–Meier survival analysis revealed that patients of the high-risk score group had highly significant shorter OS rates than those in the low-risk score group ( p < 0.0001) ( Figure 4 B).

Through statistical analyses, we confirmed the device’s efficacy in differentiating between active disease stages and remission stages, yielding a highly significant p -value of p < 0.0001.