The major bleeding was found to be 2.6% in the NOAC group and 3.5% in the warfarin group (LogOR: −0.22, 95% CI: −0.45, 0.01, P = 0.06), the differences was not significantly significant.
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Comparison of outcomes between novel oral anticoagulants and warfarin monotherapy in patients with left atrial appendage closure: A systematic review and meta-analysis.
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