Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α<sup>+</sup>thalassaemia.

The McC b allele is associated with increased susceptibility to cerebral malaria and death in the Kenyan case-control study The unadjusted analysis showed a borderline significant association between McC b and increased susceptibility to severe malaria overall (OR 1.17; 1.00–1.25; p=0.056, Supplementary file 1D ), and significant associations with increased risk of cerebral malaria (OR 1.21; 1.05–1.39; p=0.008) and death (OR 1.34; 1.00–1.77; p=0.046, Supplementary file 1D ).

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