Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole.

In this respect, the δ136Gly→Glu replacement in the eastern mole Hb may be significant as it deletes binding sites for anions (i.e., Cl - , lactate and DPG) between δ1Val and δ82Lys, thus largely freeing the 'high CO 2 affinity' δ-chain N-termini from competitive binding constraints.

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The mass spectrometry analysis of coast mole Hb also revealed highly significant matches to coast mole cDNA sequences.

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