An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.

Hum Mol Genet · 2010 · PMC2807371 · PMID 19942621

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likely to be significantno p-value reported

An adaptive algorithm was used which speeds computations by dropping SNPs less likely to be significant in each iteration.

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highly significantno p-value reported

The observed differences at a protein level in IL-6 expression of 1.7- to 2-fold associating with LEP genotype may be clinically highly significant, emphasising the potential disease relevance of these data.

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