The results showed that, compared with the LPS + sh-PTEN group, the LPS + sh-PTEN+Rapa group had significantly decreased SOD levels and significantly increased MDA levels ( P < 0.01), while the LPS + sh-PTEN + 3-MA group showed an increasing trend in SOD levels and a decreasing trend in MDA levels ( P < 0.01, Fig. 5 E).
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Knockdown of PTEN Inhibits Autophagy-Dependent Ferroptosis to Alleviate LPS-Induced Sepsis-Associated Acute Kidney Injury.
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