Association Between Diclofenac Sodium Use and Reduced Cycle Cancellation from Premature Ovulation in Women with Diminished Ovarian Reserve Undergoing IVF: A Retrospective Cohort Study.

Drug Des Devel Ther · 2026 · PMC12790961 · PMID 41926505

Europe PMC DOI

hedged sentences

0.0030

closest p · 0.1× alpha

0.0680

boldest claim

The sentences

highly significantP=0.003actually significant

After adjustment for potential confounders, this difference remained highly significant (adjusted OR 0.39, 95% CI 0.21–0.73, P=0.003), indicating a 61% reduction in the odds of cycle cancellation due to premature ovulation with diclofenac sodium administration.

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marginally non-significantP=0.068so close (0.05 < p ≤ 0.1)

Normal fertilization rates were higher in the diclofenac sodium group (82.1% vs 66.8%) but marginally non-significant after adjustment (adjusted OR 2.12, P=0.068).

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