scCirclehunter delineates ecDNA-containing cells using single-cell ATAC-seq, with a focus on glioblastoma.

Cell Discov · 2025 · PMC12686523 · PMID 41360770

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a possible trendno p-value reported

Collectively, these observations suggest a possible trend whereby checkpoint activation resulting from ecDNA genomic instability coexists with cell cycle acceleration.

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