Furthermore, C^N ligands did not show an obvious trend, with 20a -Ir and 21b -Ir being the most potent complexes against A2780 (IC 50 = 0.197 ± 0.037, 0.184 ± 0.008 μM, respectively) and A2780cisR (IC 50 = 0.261 ± 0.011, 0.077 ± 0.015 μM, respectively), which again suggests that no improvement was achieved with the unsubstituted bim fragment. 144 Laha and collaborators reported a series of Ir( iii ) complexes (22a -Ir –23b -Ir ) ( Fig. 38 ), in which they varied the auxiliary N^N ligand and the length of the aliphatic chain attached to N in the C^N bim ligand.
← all excerpts
Cyclometalated complexes: promising metallodrugs in the battle against cancer.
1
—
—