Development of the First Small-Molecule Inhibitor Targeting Oncostatin M for Treatment of Breast Cancer.

J Med Chem · 2025 · PMC12362618 · PMID 40747931

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an obvious trendno p-value reported

Although the reduction in intensity was not statistically significant, an obvious trend exists between vehicle-treated and SMI-10B13 -treated animals, suggesting SMI-10B13 , in addition to reducing tumor burden, may also prevent metastasis for breast cancer patients and increase survival ( Figure B,D).

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a trend toward significanceno p-value reported

Furthermore, SMI-10B13 was found to significantly inhibit OSM-mediated tumor growth and increase survival, with a trend toward significance in decreasing metastasis that needs to be validated in future studies.

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