Suboptimal self-reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults.

3.5 Sleep disturbance score and rate of brain Aβ accumulation After Bonferroni correction for multiple comparisons, a nominally significant three‐way interaction was observed among moderate/severe sleep disturbance, APOE ε4 carriage, and time (β = 2.35 ± 1.17, P = 0.046), with respect to rate of brain Aβ accumulation.

also in 7,732 other papers

A significant interaction for APOE ε4 carriage and time ( P = 0.001) and a trend toward significance for the three‐way interaction (moderate/severe sleep disturbance, P = 0.046, sleep duration category < 6 hours, P = 0.085, and sleep efficiency category 65%–85%, P = 0.070) confirmed modeling stratified for APOE ε4 carriage was warranted.

also in 3,729 other papers