Multi-tracer PET correlation analysis reveals disease-specific patterns in Parkinson's disease and asymptomatic LRRK2 pathogenic variant carriers compared to healthy controls.

2 d, p = 0.03) and a borderline significant correlation for MP (p = 0.05).

also in 11,409 other papers

5 a), consistent with previous findings, with highly significant loadings for the first canonical variate, underlying the strong impact of the overall loss of dopaminergic terminals.

also in 132,142 other papers

Subject scores of the asymptomatic LRRK2 pathogenic variant carriers along this canonical variate revealed an increasing trend as a function of age from negative (HCs) towards positive subject scores (PD subjects) and were significantly different from HCs (DTBZ: p < 0.0001, MP: p = 0.002) and PD subjects scores (both tracers p < 0.0001).

also in 63,971 other papers